Need of voriconazole high dosages, with documented cerebrospinal fluid penetration, for treatment of cerebral aspergillosis in a 6-month-old leukaemic girl

Elena Palmisani; Sebastiano Barco; Giuliana Cangemi; Cristina Moroni; Carlo Dufour; Elio Castagnola

doi:10.1179/1973947815Y.0000000009

Need of voriconazole high dosages, with documented cerebrospinal fluid penetration, for treatment of cerebral aspergillosis in a 6-month-old leukaemic girl

Elena Palmisani, Sebastiano Barco, Giuliana Cangemi, Cristina Moroni, Carlo Dufour, Elio Castagnola

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

This case report indicates the usefulness of voriconazole for the treatment of central nervous system (CNS) aspergillosis, also in paediatrics. However, it also confirms the need for therapeutic drug monitoring (TDM), especially in younger children that may require very high dosages in order to achieve plasma and cerebrospinal fluid (CSF) therapeutic concentrations.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Journal of Chemotherapy
DOIs	https://doi.org/10.1179/1973947815Y.0000000009
Publication status	Accepted/In press - Apr 7 2016

Keywords

Cerebral aspergillosis
Cerebrospinal fluid concentrations
Children
Leukaemia
Voriconazole

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Oncology
Pharmacology

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10.1179/1973947815Y.0000000009

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Need of voriconazole high dosages, with documented cerebrospinal fluid penetration, for treatment of cerebral aspergillosis in a 6-month-old leukaemic girl. / Palmisani, Elena; Barco, Sebastiano ; Cangemi, Giuliana; Moroni, Cristina; Dufour, Carlo; Castagnola, Elio.

In: Journal of Chemotherapy, 07.04.2016, p. 1-3.

Research output: Contribution to journal › Article › peer-review

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AU - Dufour, Carlo

AU - Castagnola, Elio

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Need of voriconazole high dosages, with documented cerebrospinal fluid penetration, for treatment of cerebral aspergillosis in a 6-month-old leukaemic girl

Abstract

Keywords

ASJC Scopus subject areas

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