Need of voriconazole high dosages, with documented cerebrospinal fluid penetration, for treatment of cerebral aspergillosis in a 6-month-old leukaemic girl

Elena Palmisani, Sebastiano Barco, Giuliana Cangemi, Cristina Moroni, Carlo Dufour, Elio Castagnola

Research output: Contribution to journalArticlepeer-review

Abstract

This case report indicates the usefulness of voriconazole for the treatment of central nervous system (CNS) aspergillosis, also in paediatrics. However, it also confirms the need for therapeutic drug monitoring (TDM), especially in younger children that may require very high dosages in order to achieve plasma and cerebrospinal fluid (CSF) therapeutic concentrations.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalJournal of Chemotherapy
DOIs
Publication statusAccepted/In press - Apr 7 2016

Keywords

  • Cerebral aspergillosis
  • Cerebrospinal fluid concentrations
  • Children
  • Leukaemia
  • Voriconazole

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Oncology
  • Pharmacology

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