Negative concordance pattern in bipolar and unipolar recordings: An additional mapping criterion to localize the site of origin of focal ventricular arrhythmias

Antonio Sorgente, Gianluca Epicoco, Hussam Ali, Sara Foresti, Guido de Ambroggi, Cristina Balla, Gianluca Bonitta, Marco Matteo Ciccone, Pierpaolo Lupo, Riccardo Cappato

Research output: Contribution to journalArticle

Abstract

Background The relevance of the temporal relationship between a unipolar electrogram (UEGM) and a bipolar electrogram (BEGM) in determining the site of origin (SOO) of focal arrhythmias has been largely demonstrated. Objective We sought to demonstrate that a negative concordance in the initial forces of these EGMs is also helpful in predicting the SOO of premature ventricular contractions (PVCs). Methods Mapping and radiofrequency (RF) ablation were performed in 41 patients with symptomatic PVCs in the absence of structural heart disease. Simultaneous recordings of the minimally filtered (0.5-500 Hz) UEGM and filtered BEGM (30-500 Hz) were analyzed at 247 mapping sites, where RF was attempted. EGMs of 63 mechanically induced PVCs were separately analyzed as a validation group. All ablation sites had a QS pattern in the UEGM. Acute PVC suppression was defined as a complete disappearance of ventricular ectopic beats after a 60-second pulse of RF. Results RF ablation obtained PVC suppression (RF+) in 33 of 247 sites (13.3%). A negative concordance pattern (NCP) during the initial 20 ms of both UEGM and BEGM was observed in 31 of 33 (94%) RF+ sites compared with 10 of 214 (4%)RF- sites (P
Original languageEnglish
Pages (from-to)519-526
Number of pages8
JournalHeart Rhythm
Volume13
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • Bipolar recording
  • Catheter ablation
  • Premature ventricular contraction
  • Unipolar recording

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