Negative correlation between ICA persistence and beta cell restoration after IDDM diagnosis

R. Manna; M. Salvatore; F. Scuderi; G. Papa; G. Marietti; A. V. Greco; G. Ghirlanda; G. Gambassi

Negative correlation between ICA persistence and beta cell restoration after IDDM diagnosis

R. Manna, M. Salvatore, F. Scuderi, G. Papa, G. Marietti, A. V. Greco, G. Ghirlanda, G. Gambassi

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Abstract

We have studied 27 insulin-dependent diabetic patients since diagnosis for a period of six months; at diabetes onset and later on, ICA were found in 17 of them, whereas they were undetectable in 10 patients: age was remarkably homogeneous in the two groups. At diabetes onset, no significant differences were found in insulin requirement between ICA positive and ICA negative patients; however, six months after diagnosis, we observed that insulin requirement to keep metabolic control was significantly higher in ICA positive than in ICA negative subjects (0.515±0.2 U/Kg versus 0.22±0.15 U/Kg, p

Original language	English
Pages (from-to)	101-103
Number of pages	3
Journal	Diabetes Research
Volume	9
Issue number	3
Publication status	Published - 1988

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism
Internal Medicine

Cite this

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abstract = "We have studied 27 insulin-dependent diabetic patients since diagnosis for a period of six months; at diabetes onset and later on, ICA were found in 17 of them, whereas they were undetectable in 10 patients: age was remarkably homogeneous in the two groups. At diabetes onset, no significant differences were found in insulin requirement between ICA positive and ICA negative patients; however, six months after diagnosis, we observed that insulin requirement to keep metabolic control was significantly higher in ICA positive than in ICA negative subjects (0.515±0.2 U/Kg versus 0.22±0.15 U/Kg, p",

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T1 - Negative correlation between ICA persistence and beta cell restoration after IDDM diagnosis

AU - Manna, R.

AU - Salvatore, M.

AU - Scuderi, F.

AU - Papa, G.

AU - Marietti, G.

AU - Greco, A. V.

AU - Ghirlanda, G.

AU - Gambassi, G.

PY - 1988

Y1 - 1988

N2 - We have studied 27 insulin-dependent diabetic patients since diagnosis for a period of six months; at diabetes onset and later on, ICA were found in 17 of them, whereas they were undetectable in 10 patients: age was remarkably homogeneous in the two groups. At diabetes onset, no significant differences were found in insulin requirement between ICA positive and ICA negative patients; however, six months after diagnosis, we observed that insulin requirement to keep metabolic control was significantly higher in ICA positive than in ICA negative subjects (0.515±0.2 U/Kg versus 0.22±0.15 U/Kg, p

AB - We have studied 27 insulin-dependent diabetic patients since diagnosis for a period of six months; at diabetes onset and later on, ICA were found in 17 of them, whereas they were undetectable in 10 patients: age was remarkably homogeneous in the two groups. At diabetes onset, no significant differences were found in insulin requirement between ICA positive and ICA negative patients; however, six months after diagnosis, we observed that insulin requirement to keep metabolic control was significantly higher in ICA positive than in ICA negative subjects (0.515±0.2 U/Kg versus 0.22±0.15 U/Kg, p

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SP - 101

EP - 103

JO - Diabetes Research

JF - Diabetes Research

SN - 0265-5985

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Negative correlation between ICA persistence and beta cell restoration after IDDM diagnosis

Abstract

ASJC Scopus subject areas

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