Negative evidence for an adaptive response to lethal and mutagenic effects of alkylating agents in V79 Chinese hamster cells

G. Frosina; S. Bonatti; A. Abbondandolo

doi:10.1016/0027-5107(84)90157-X

Negative evidence for an adaptive response to lethal and mutagenic effects of alkylating agents in V79 Chinese hamster cells

G. Frosina, S. Bonatti, A. Abbondandolo

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

V79 Chinese hamster cells were subjected to a number of different pretreatment regimens with low concentrations of N-methyl-N-nitrosourea (MNU), N-ethyl-N-nitrosourea (ENU) or N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). They were then treated with either MNU or ENU at toxic and mutagenic concentrations. No differences in cell killing or mutation induction to 6-thioguanine resistance were found between pretreated and non-pretreated cells. These results argue against the existence of an adaptive response to alkylating agents in this cell line.

Original language	English
Pages (from-to)	243-250
Number of pages	8
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	129
Issue number	2
DOIs	https://doi.org/10.1016/0027-5107(84)90157-X
Publication status	Published - 1984

ASJC Scopus subject areas

Molecular Biology
Health, Toxicology and Mutagenesis
Medicine(all)

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abstract = "V79 Chinese hamster cells were subjected to a number of different pretreatment regimens with low concentrations of N-methyl-N-nitrosourea (MNU), N-ethyl-N-nitrosourea (ENU) or N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). They were then treated with either MNU or ENU at toxic and mutagenic concentrations. No differences in cell killing or mutation induction to 6-thioguanine resistance were found between pretreated and non-pretreated cells. These results argue against the existence of an adaptive response to alkylating agents in this cell line.",

author = "G. Frosina and S. Bonatti and A. Abbondandolo",

year = "1984",

doi = "10.1016/0027-5107(84)90157-X",

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T1 - Negative evidence for an adaptive response to lethal and mutagenic effects of alkylating agents in V79 Chinese hamster cells

AU - Frosina, G.

AU - Bonatti, S.

AU - Abbondandolo, A.

PY - 1984

Y1 - 1984

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AB - V79 Chinese hamster cells were subjected to a number of different pretreatment regimens with low concentrations of N-methyl-N-nitrosourea (MNU), N-ethyl-N-nitrosourea (ENU) or N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). They were then treated with either MNU or ENU at toxic and mutagenic concentrations. No differences in cell killing or mutation induction to 6-thioguanine resistance were found between pretreated and non-pretreated cells. These results argue against the existence of an adaptive response to alkylating agents in this cell line.

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Negative evidence for an adaptive response to lethal and mutagenic effects of alkylating agents in V79 Chinese hamster cells

Abstract

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