Abstract
V79 Chinese hamster cells were subjected to a number of different pretreatment regimens with low concentrations of N-methyl-N-nitrosourea (MNU), N-ethyl-N-nitrosourea (ENU) or N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). They were then treated with either MNU or ENU at toxic and mutagenic concentrations. No differences in cell killing or mutation induction to 6-thioguanine resistance were found between pretreated and non-pretreated cells. These results argue against the existence of an adaptive response to alkylating agents in this cell line.
| Original language | English |
|---|---|
| Pages (from-to) | 243-250 |
| Number of pages | 8 |
| Journal | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
| Volume | 129 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Molecular Biology
- Health, Toxicology and Mutagenesis
- Medicine(all)
Cite this
Negative evidence for an adaptive response to lethal and mutagenic effects of alkylating agents in V79 Chinese hamster cells. / Frosina, G.; Bonatti, S.; Abbondandolo, A.
In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 129, No. 2, 1984, p. 243-250.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Negative evidence for an adaptive response to lethal and mutagenic effects of alkylating agents in V79 Chinese hamster cells
AU - Frosina, G.
AU - Bonatti, S.
AU - Abbondandolo, A.
PY - 1984
Y1 - 1984
N2 - V79 Chinese hamster cells were subjected to a number of different pretreatment regimens with low concentrations of N-methyl-N-nitrosourea (MNU), N-ethyl-N-nitrosourea (ENU) or N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). They were then treated with either MNU or ENU at toxic and mutagenic concentrations. No differences in cell killing or mutation induction to 6-thioguanine resistance were found between pretreated and non-pretreated cells. These results argue against the existence of an adaptive response to alkylating agents in this cell line.
AB - V79 Chinese hamster cells were subjected to a number of different pretreatment regimens with low concentrations of N-methyl-N-nitrosourea (MNU), N-ethyl-N-nitrosourea (ENU) or N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). They were then treated with either MNU or ENU at toxic and mutagenic concentrations. No differences in cell killing or mutation induction to 6-thioguanine resistance were found between pretreated and non-pretreated cells. These results argue against the existence of an adaptive response to alkylating agents in this cell line.
UR - http://www.scopus.com/inward/record.url?scp=0021720920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021720920&partnerID=8YFLogxK
U2 - 10.1016/0027-5107(84)90157-X
DO - 10.1016/0027-5107(84)90157-X
M3 - Article
C2 - 6504063
AN - SCOPUS:0021720920
VL - 129
SP - 243
EP - 250
JO - Mutation Research
JF - Mutation Research
SN - 0027-5107
IS - 2
ER -