Abstract
V79 Chinese hamster cells were subjected to a number of different pretreatment regimens with low concentrations of N-methyl-N-nitrosourea (MNU), N-ethyl-N-nitrosourea (ENU) or N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). They were then treated with either MNU or ENU at toxic and mutagenic concentrations. No differences in cell killing or mutation induction to 6-thioguanine resistance were found between pretreated and non-pretreated cells. These results argue against the existence of an adaptive response to alkylating agents in this cell line.
Original language | English |
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Pages (from-to) | 243-250 |
Number of pages | 8 |
Journal | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
Volume | 129 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1984 |
ASJC Scopus subject areas
- Molecular Biology
- Health, Toxicology and Mutagenesis
- Medicine(all)