Negative myoclonus induced by cortical electrical stimulation in epileptic patients

Guido Rubboli, Roberto Mai, Stefano Meletti, Stefano Francione, Francesco Cardinale, Laura Tassi, Giorgio Lo Russo, Michelangelo Stanzani-Maserati, Gaetano Cantalupo, Carlo Alberto Tassinari

Research output: Contribution to journalArticlepeer-review

Abstract

Negative myoclonus (NM) is a motor disorder characterized by a sudden and abrupt interruption of muscular activity. The EMG correlate of NM is a brief (80% of stimuli; (ii) the stimulation of SI at low stimulus intensities (from 0.4 to 0.8 mA) induced in two patients only SPs, never associated with an antecedent MEP, whereas in the third subject the SPs could be inconstantly preceded by an MEP; by incrementing the stimulus intensity (up to 3 mA), in all three patients the SPs tended to be preceded, although not constantly, by an MEP; stimulus intensity affected SP duration (i.e. the higher the intensity, the longer the SP), without influencing the latency of onset of the SPs; (iii) the stimulation of SMA induced only pure SPs, at all stimulus intensities up to 3 mA; as for SI, increment of stimulus intensity was paralleled by an increase in SP duration, without influencing the onset latency of SPs. We conclude that single electric pulse stimulation of PMC, MI, SI and SMA through stereo-EEG electrodes can induce pure SPs, not preceded by an MEP, which clinically appear as NM, suggesting therefore that these cortical areas may be involved in the genesis of this motor phenomenon. However, it must be pointed out that SMA stimulation induced only pure SPs, regardless of the stimulus intensity, whereas occurrence of pure SPs following stimulation of PMC, MI, and SI depended mainly on the intensity of stimulation.

Original languageEnglish
Pages (from-to)65-81
Number of pages17
JournalBrain
Volume129
Issue number1
DOIs
Publication statusPublished - Jan 2006

Keywords

  • Intracerebral electrical stimulation
  • Negative myoclonus
  • Primary somatosensory cortex
  • Silent period
  • Supplementary motor area

ASJC Scopus subject areas

  • Neuroscience(all)

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