Negative pigment network and shiny white streaks: A dermoscopic- pathological correlation study

Maria A. Pizzichetta, Vincenzo Canzonieri, Peter H. Soyer, Pietro Rubegni, Renato Talamini, Cesare Massone

Research output: Contribution to journalArticlepeer-review

Abstract

It has been suggested that both negative pigment network (NPN) and shiny white streaks (SWS) were related to an increase of dermal collagen. To study precisely the dermoscopic-histopathologic correlation of NPN and SWS, we have performed a dermoscopic-pathological correlation study. A total of 25 skin lesions dermoscopically characterized by the presence of NPN and/or SWS, including histopathologically confirmed dermatofibroma (2), Spitz nevus (3), compound nevus (6), dysplastic nevus (7), and melanoma (7), were evaluated for the presence of NPN, SWS, and blue-white veil. The histopathologic features such as orthokeratosis, orthokeratosis plus nests of pigmented melanocytes at the junction, hypergranulosis, hypergranulosis plus nests of pigmented melanocytes at the junction, epidermal invagination plus orthokeratosis, fibrosis, lamellar fibrosis, and elongation and bridging of rete ridges were evaluated. We found a disagreement in 80% of skin lesions between NPN and fibrosis (P = 0.02). For SWS, a significant agreement emerged with hypergranulosis (76%; P = 0.01), and the same occurred with fibrosis (80%; P = 0.01). Moreover, blue-white veil also displayed a significant agreement with hypergranulosis (68%; P = 0.04). Our findings confirm the correlation of SWS with fibrosis, whereas a clear-cut histopathologic substrate of NPN could not be established.

Original languageEnglish
Pages (from-to)433-438
Number of pages6
JournalAmerican Journal of Dermatopathology
Volume36
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • dermatofibroma
  • melanocytic nevi
  • melanoma
  • negative pigment network
  • shiny white streaks
  • Spitz nevus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology
  • Medicine(all)

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