Negative potential shifts and the prediction of the outcome of neurofeedback therapy in epilepsy

B. Kotchoubey, U. Strehl, S. Holzapfel, V. Blankenhorn, W. Fröscher, N. Birbaumer

Research output: Contribution to journalArticle

Abstract

About two-thirds of epilepsy patients who learn to control their slow cortical potential shifts (SCP) reduce their seizure rate, but the remaining third does not demonstrate clinical improvement. In the present study, this finding was replicated in a group of 27 patients with focal epilepsy. We found that patients who consistently produced larger negative SCP in all conditions during the first phase of treatment, showed no decrease in seizure frequency during the six-month follow-up, as compared with the three-month baseline phase. The large negative SCP explained about one-third of the variance of the clinical outcome. Age, medication, seizure history, or the localization of focus were found to be unrelated to clinical improvement.

Original languageEnglish
Pages (from-to)683-686
Number of pages4
JournalClinical Neurophysiology
Volume110
Issue number4
DOIs
Publication statusPublished - Apr 1 1999

Keywords

  • Epilepsy
  • Outcome prediction
  • Self-regulation
  • Slow conical potentials

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems

Fingerprint Dive into the research topics of 'Negative potential shifts and the prediction of the outcome of neurofeedback therapy in epilepsy'. Together they form a unique fingerprint.

  • Cite this

    Kotchoubey, B., Strehl, U., Holzapfel, S., Blankenhorn, V., Fröscher, W., & Birbaumer, N. (1999). Negative potential shifts and the prediction of the outcome of neurofeedback therapy in epilepsy. Clinical Neurophysiology, 110(4), 683-686. https://doi.org/10.1016/S1388-2457(99)00005-X