Negative pressure ventilation vs external high-frequency oscillation during rigid bronchoscopy: A controlled randomized trial

Giuseppe Natalini, Sergio Cavaliere, Veronica Seramondi, Pierfranco Foccoli, Michele Vitacca, Nicolino Ambrosino, Andrea Candiani

Research output: Contribution to journalArticlepeer-review


Study objectives: To compare the effectiveness of two modalities of external ventilation during rigid bronchoscopy: intermittent negative pressure ventilation (INPV) and external high-frequency oscillation (EHFO). Design: Prospective, controlled, randomized, nonblinded study. Setting: University-affiliated hospital. Patients: Seventy patients undergoing interventional rigid bronchoscopy for tracheobronchial lesions were enrolled into the study. Interventions: Mechanical ventilation was performed by INPV or EHFO. When pulse oximetry was <90%, manually assisted ventilation was delivered. Measurements and results: Arterial blood gases were sampled preoperatively and intraoperatively. Most patients in both groups bad normal intraoperative PaCO2 (mean, 43.6 ± 11.8 mm Hg under EHFO and 37.4 ± 8.2 mm Hg under INPV; p = 0.012), and acidemia occurred in 9 of 85 patients of EHFO group and in 2 of 35 patients of INPV group (p = 0.049). Hypercapnia (PaCO2 > 50 mm Hg) was observed in 10 patients under EHFO and in 2 with INPV (p = 0.026). Intraoperative mean PaO2 was similar (101.4 ± 52.9 mm Hg with EHFO and 124.2 ± 50.3 mm Hg with INPV; p = 0.07), but O2 supply was different (3.5 ± 2.3 L/min during INPV and 8.5 ± 6.2 L/min during EHFO; p <0.001). Intraoperative hypoxemia (PaO2 <60 mm Hg) occurred in five patients with EHFO and two with INPV (p = 0.426). Three EHFO patients required manually assisted ventilation (mean, 0.2 ± 0.9), but no INPV patient did (p = 0.142). Conclusions: External negative pressure ventilation appears to be a suitable choice during rigid bronchoscopy: both EHFO and INPV ensure effective ventilation and comfortable operating conditions in the majority of patients. Some patients may receive inadequate ventilation with EHFO, developing respiratory acidosis and requiring manually assisted ventilation. In comparison with INPV, EHFO requires a higher fraction of inspired oxygen.

Original languageEnglish
Pages (from-to)18-23
Number of pages6
Issue number1
Publication statusPublished - 2000


  • Anesthesia
  • Artificial ventilators
  • Bronchoscopy
  • High-frequency ventilation
  • Negative-pressure
  • Respiration

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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