Negative regulation of receptor tyrosine kinase signals

Monia Fiorini, Maurizio Alimandi, Loredana Fiorentino, Gianluca Sala, Oreste Segatto

Research output: Contribution to journalArticlepeer-review


In Metazoans a number of cellular functions are controlled by receptor tyrosine kinases (RTKs) during development and in postnatal life. The execution of these programs requires that signals of adequate strength are delivered for the appropriate time within precise spatial boundaries. Several RTK inhibitors have been identified in invertebrate and mammalian organisms. Because they are involved in tuning and termination of receptor signals, negative regulators of RTK activity fulfill a fundamental function in the control of receptor signaling.

Original languageEnglish
Pages (from-to)132-141
Number of pages10
JournalFEBS Letters
Issue number3
Publication statusPublished - Feb 16 2001


  • Cell cycle
  • Feedback inhibitor
  • Negative signaling
  • Receptor tyrosine kinase
  • Signal inhibition

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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