Negative results of short-term genotoxicity tests with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene

Tommaso A. Dragani, Roberto Barale, Silvio Parodi, Maurizio Taningher, Donatella Zucconi, Giuseppe Della Porta

Research output: Contribution to journalArticle

Abstract

The phenobarbital-like enzyme inducer and tumor promoter of murine hepatocarcinogenesis, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene has been assayed in short-term genotoxicity tests, i.e. the Salmonella mutagenicity test, micronucleus and chromosomal aberrations analysis in mouse bone marrow cells in vivo, DNA alkaline elution and DNA unwinding assays in mouse liver in vivo. All the assays performed proved negative.

Original languageEnglish
Pages (from-to)1153-1157
Number of pages5
JournalCarcinogenesis
Volume11
Issue number7
Publication statusPublished - Jul 1990

Fingerprint

Mutagenicity Tests
Mouse
Assays
Benzene
DNA
Salmonella
Phenobarbital
Aberrations
Aberration
Bone
Promoter
Chromosome Aberrations
Bone Marrow Cells
Carcinogens
Liver
Tumors
Tumor
Enzymes
Cells
Cell

ASJC Scopus subject areas

  • Cancer Research
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Behavioral Neuroscience

Cite this

Dragani, T. A., Barale, R., Parodi, S., Taningher, M., Zucconi, D., & Della Porta, G. (1990). Negative results of short-term genotoxicity tests with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene. Carcinogenesis, 11(7), 1153-1157.

Negative results of short-term genotoxicity tests with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene. / Dragani, Tommaso A.; Barale, Roberto; Parodi, Silvio; Taningher, Maurizio; Zucconi, Donatella; Della Porta, Giuseppe.

In: Carcinogenesis, Vol. 11, No. 7, 07.1990, p. 1153-1157.

Research output: Contribution to journalArticle

Dragani, TA, Barale, R, Parodi, S, Taningher, M, Zucconi, D & Della Porta, G 1990, 'Negative results of short-term genotoxicity tests with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene', Carcinogenesis, vol. 11, no. 7, pp. 1153-1157.
Dragani TA, Barale R, Parodi S, Taningher M, Zucconi D, Della Porta G. Negative results of short-term genotoxicity tests with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene. Carcinogenesis. 1990 Jul;11(7):1153-1157.
Dragani, Tommaso A. ; Barale, Roberto ; Parodi, Silvio ; Taningher, Maurizio ; Zucconi, Donatella ; Della Porta, Giuseppe. / Negative results of short-term genotoxicity tests with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene. In: Carcinogenesis. 1990 ; Vol. 11, No. 7. pp. 1153-1157.
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