Negative signalling via the P58/NKR for HLA.C alleles.

M. Vitale, S. Sivori, L. Sanseverino, M. Barbaresi, L. Morelli, L. Olcese, R. Agugliano, C. Bottino, A. Moretta

Research output: Contribution to journalArticlepeer-review


Recent studies have demonstrated that the interaction between HLA class I alleles and specific NK receptors results in negative signals which inhibit NK-mediated cytotoxicity. Such NK receptors have been identified by GL183 and EB6 mAbs which recognize distinct members of a molecular family involved in the recognition of two groups of HLA.C alleles. Now we describe a new allospecific NK group (group 0) which recognize all HLA.C alleles and we demonstrate that, on these clones, the p58 molecules EB6 and GL183 act independently to recognize Cw4 (and related alleles) and Cw3 (and related alleles) respectively. Finally we investigate whether the inhibitory signal mediated by the NK-receptor for HLA.C induce a temporary turn off on the cytolytic activity.

Original languageEnglish
Pages (from-to)69-76
Number of pages8
JournalEuropean journal of histochemistry : EJH
Volume38 Suppl 1
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Cell Biology
  • Developmental Biology
  • Anatomy


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