Negative signals from FcεRI engagement attenuate mast cell functions

Rosa Molfetta, Giovanna Peruzzi, Angela Santoni, Rossella Paolini

Research output: Contribution to journalArticlepeer-review


Mast cells have long been recognized as the critical tissue-based effector cells in IgE-mediated allergic diseases. Ligation of the high-affinity receptor for IgE (FcεRI), constitutively expressed on mast cells, promotes cell activation and immediate release and production of pro-inflammatory mediators. Besides these positive signals, FcεRI aggregation has recently been understood to generate negative intracellular signals capable of limiting mast cell functional responses. This review is aimed at providing a summary of the mechanisms through which FcεRI engagement can generate negative signals and regulate mast-cell function. Similar mechanisms are employed by other receptors expressed by immune cells, such as T cell and B cell receptors, pointing to a general concept in negative immunoreceptor signaling.

Original languageEnglish
Pages (from-to)219-229
Number of pages11
JournalArchivum Immunologiae et Therapiae Experimentalis
Issue number4
Publication statusPublished - Aug 2007


  • FcεRI
  • Mast cell
  • Negative regulation
  • Signal transduction

ASJC Scopus subject areas

  • Immunology


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