Neisseria gonorrhoeae ciprofloxacin-resistant strains were associated with Chlamydia trachomatis coinfection

Lucia Corich, Giuseppina Campisciano, Nunzia Zanotta, Lorenzo Monasta, Vincenzo Petix, Beatrice Favero, Claudia Colli, Francesco De Seta, Manola Comar

Research output: Contribution to journalArticle

Abstract

Aim: This study aims to characterize circulating strains to predict their relationship with sexually transmitted microorganisms, Chlamydia trachomatis, HIV, HCV, Treponema pallidum, HPV, Mycoplasmas, in an Italian multiethnic area, which has revealed a recent increase of Neisseria gonorrhoeae first-line antibiotic resistance. Materials & methods: We performed N. gonorrhoeae multiantigen sequence typing and the N. gonorrhoeae sequence typing for antimicrobial resistance. Results: We identified mutations in genes conferring resistance to cephalosporins, macrolides, fluoroquinolones through por and tbpB loci, and we reported new combinations of already known alleles. N. gonorrhoeae resistance to ciprofloxacin was associated with C. trachomatis coinfection. Conclusion: This study's data proved the utility of a routine N. gonorrhoeae molecular characterization to monitor the evolution of antibiotic resistance and to detect the most effective clinical treatment.

Original languageEnglish
Pages (from-to)653-660
Number of pages8
JournalFuture Microbiology
Volume14
Issue number8
DOIs
Publication statusPublished - Jan 1 2019

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Keywords

  • Chlamydia trachomatis
  • ciprofloxacin
  • Neisseria gonorrhoeae
  • productive health

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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