Neoadjuvant chemotherapy for Non-Small-Cell lung cancer: Does it really impact on postoperative outcome after lung resection?

L. Voltolini, C. Rapicetta, T. Ligabue, S. Scolletta, C. Ghiribelli, G. Gotti

Research output: Contribution to journalArticle

Abstract

BACKGROUND Although some studies seem to indicate a positive prognostic value of induction chemotherapy in patients with locally advanced Non-Small-Cell Lung Cancer (NSCLC), its impact on postoperative mortality and morbidity is not well established. MATERIALS AND METHODS We reviewed the records of 83 consecutive patients who underwent thoracotomy after induction therapy between 1996 and 2007 (Group 1). Results were compared to those of a control group of 166 patients surgically treated in the same period without prior neoadjuvant therapy (Group 2). RESULTS The two groups were matched for age, sex, histology, comorbidity, respiratory function, and surgical procedure. There was no hospital mortality. Cumulative incidence of major complications was 32% in Group 1 and 37% in Group 2 (p=0.18). The incidence of each complication considered did not significantly differ between the two groups. A higher percentage of patients in Group 1 required blood transfusions (21.7% vs 4.2%, p

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalEuropean journal of Clinical and Medical Oncology
Volume3
Issue number2
Publication statusPublished - 2011

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Keywords

  • Chemotherapy
  • Complications
  • Lung cancer
  • Mortality

ASJC Scopus subject areas

  • Oncology

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