Neoadjuvant chemotherapy for osteosarcoma of the extremity

G. Bacci; D. Springfield; R. Capanna; P. Picci; A. Guerra; U. Albissini; P. Ruggieri; R. Biagini; M. Campanacci

Neoadjuvant chemotherapy for osteosarcoma of the extremity

G. Bacci, D. Springfield, R. Capanna, P. Picci, A. Guerra, U. Albissini, P. Ruggieri, R. Biagini, M. Campanacci

Research output: Contribution to journal › Article › peer-review

Abstract

Eighty-five patients with nonmetastatic, highgrade osteosarcoma of an extremity recieved intravenous methotrexate and intraarterial cisplatinum and then a definitive surgical resection. The preliminary results suggest that preoperative chemotherapy with a delayed surgical resection is as safe as immediate surgery. More patients are candidates for limb salvage after chemotherapy. The tumor response to the preoperative chemotherapy also has prognostic value. Reducing the postoperative chemotherapy can be dangerous. A high dose methotrexate may not be necessary.

Original language	English
Pages (from-to)	268-276
Number of pages	9
Journal	Clinical Orthopaedics and Related Research
Issue number	224
Publication status	Published - 1987

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Surgery

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title = "Neoadjuvant chemotherapy for osteosarcoma of the extremity",

abstract = "Eighty-five patients with nonmetastatic, highgrade osteosarcoma of an extremity recieved intravenous methotrexate and intraarterial cisplatinum and then a definitive surgical resection. The preliminary results suggest that preoperative chemotherapy with a delayed surgical resection is as safe as immediate surgery. More patients are candidates for limb salvage after chemotherapy. The tumor response to the preoperative chemotherapy also has prognostic value. Reducing the postoperative chemotherapy can be dangerous. A high dose methotrexate may not be necessary.",

author = "G. Bacci and D. Springfield and R. Capanna and P. Picci and A. Guerra and U. Albissini and P. Ruggieri and R. Biagini and M. Campanacci",

year = "1987",

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T1 - Neoadjuvant chemotherapy for osteosarcoma of the extremity

AU - Bacci, G.

AU - Springfield, D.

AU - Capanna, R.

AU - Picci, P.

AU - Guerra, A.

AU - Albissini, U.

AU - Ruggieri, P.

AU - Biagini, R.

AU - Campanacci, M.

PY - 1987

Y1 - 1987

N2 - Eighty-five patients with nonmetastatic, highgrade osteosarcoma of an extremity recieved intravenous methotrexate and intraarterial cisplatinum and then a definitive surgical resection. The preliminary results suggest that preoperative chemotherapy with a delayed surgical resection is as safe as immediate surgery. More patients are candidates for limb salvage after chemotherapy. The tumor response to the preoperative chemotherapy also has prognostic value. Reducing the postoperative chemotherapy can be dangerous. A high dose methotrexate may not be necessary.

AB - Eighty-five patients with nonmetastatic, highgrade osteosarcoma of an extremity recieved intravenous methotrexate and intraarterial cisplatinum and then a definitive surgical resection. The preliminary results suggest that preoperative chemotherapy with a delayed surgical resection is as safe as immediate surgery. More patients are candidates for limb salvage after chemotherapy. The tumor response to the preoperative chemotherapy also has prognostic value. Reducing the postoperative chemotherapy can be dangerous. A high dose methotrexate may not be necessary.

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JO - Clinical Orthopaedics and Related Research

JF - Clinical Orthopaedics and Related Research

SN - 0009-921X

IS - 224

ER -

Neoadjuvant chemotherapy for osteosarcoma of the extremity

Abstract

ASJC Scopus subject areas

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