TY - JOUR
T1 - Neoadjuvant chemotherapy for patients with synchronous multifocal osteosarcoma
T2 - Results in eleven cases
AU - Longhi, A.
AU - Fabbri, N.
AU - Donati, D.
AU - Capanna, R.
AU - Briccoli, A.
AU - Biagini, R.
AU - Bernini, G.
AU - Ferrari, S.
AU - Versari, M.
AU - Bacci, G.
PY - 2001
Y1 - 2001
N2 - Between January 1995 and December 1999, 11 patients with synchronous multifocal osteosarcoma (SMO) received neoadjuvant treatment with high-dose methotrexate, cisplatinum, Adriamycin, and ifosfamide. After primary chemotherapy in 4 patients who had only two bone localizations, it was possible to treat all tumor foci locally. The remaining patients, with more than three bones involved, were treated surgically only in 3 cases at the primary site, while secondary lesions did not receive any treatment. The final results of our study were disappointing. All patients died of the tumor 6 to 24 months after the beginning of treatment (mean 11.9 months). Nevertheless, the survival time of the 4 patients with locally treated lesions was significantly longer than the one of 7 patients in whom the secondary lesions were not locally treated (18.2 vs 9.1 months; P
AB - Between January 1995 and December 1999, 11 patients with synchronous multifocal osteosarcoma (SMO) received neoadjuvant treatment with high-dose methotrexate, cisplatinum, Adriamycin, and ifosfamide. After primary chemotherapy in 4 patients who had only two bone localizations, it was possible to treat all tumor foci locally. The remaining patients, with more than three bones involved, were treated surgically only in 3 cases at the primary site, while secondary lesions did not receive any treatment. The final results of our study were disappointing. All patients died of the tumor 6 to 24 months after the beginning of treatment (mean 11.9 months). Nevertheless, the survival time of the 4 patients with locally treated lesions was significantly longer than the one of 7 patients in whom the secondary lesions were not locally treated (18.2 vs 9.1 months; P
KW - Adriamycin
KW - Cisplatin
KW - Ifosfamide
KW - Methotrexate
KW - Multifocal osteosarcoma
KW - Osteosarcoma
KW - Synchronous multifocal osteosarcoma
UR - http://www.scopus.com/inward/record.url?scp=0034978751&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034978751&partnerID=8YFLogxK
M3 - Article
C2 - 11450892
AN - SCOPUS:0034978751
VL - 13
SP - 324
EP - 330
JO - Journal of Chemotherapy
JF - Journal of Chemotherapy
SN - 1120-009X
IS - 3
ER -