Neoadjuvant chemotherapy in cervical cancer: An update

Research output: Contribution to journalArticle

Abstract

The role of neoadjuvant chemotherapy (NACT) has been investigated in order to improve prognosis of patients with locally advanced cervical cancer. According to a meta-analysis, NACT followed by radiotherapy may be detrimental with a low dose of cisplatin and longer cycle intervals. Some meta-analyses showed NACT followed by surgery resulted in a reduction in the risk of death by 35% with a gain of 14% in the 5-year survival compared with radiotherapy. In a Cochrane meta-analysis, overall survival and progression-free survival were significantly improved with NACT followed by surgery versus surgery alone (23% reduction in the risk of death). The platinum/paclitaxel combination is now the preferred regimen in the neoadjuvant setting and preliminary data indicate that dose-dense regimens are feasible and effective (overall response rate: 67.8-87%). A weekly regimen with carboplatin/paclitaxel before chemoradiation showed promising results and the INTERLACE ongoing trial will help to confirm whether additional short-course chemotherapy given weekly before chemoradiation will lead to an improvement in overall survival.

Original languageEnglish
Pages (from-to)1171-1181
Number of pages11
JournalExpert Review of Anticancer Therapy
Volume15
Issue number10
DOIs
Publication statusPublished - Oct 3 2015

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Keywords

  • emerging therapies
  • locally advanced cervical cancer
  • neoadjuvant chemotherapy
  • radiotherapy
  • surgery

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

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