Neoadjuvant chemotherapy in the treatment of osteosarcoma of the extremities: Preliminary results in 131 cases treated preoperatively with methotrexate and cisdiamminoplatinum

G. Bacci, M. Avella, R. Capanna, S. Boriani, D. Dallari, S. Galletti, A. Giunti, E. Madon, A. Mancini, M. Mercuri, M. Orlandi, G. Padovani, P. Picci, A. Sudanese, M. Campanacci

Research output: Contribution to journalArticle

Abstract

The results of 131 cases of classic non-metastatic osteosarcoma of the extremities treated with preoperative chemotherapy, surgery and postoperative chemotherapy are reported. Preoperatively, the patients were given Methotrexate (MTX) intravenously (high and average doses) and Cisplatinum (CDP) intraarterially. For postoperative chemotherapy, the drugs and treatment protocols were based on the degree of necrosis observed (good, fair, poor). Conservative surgery was performed in 73% of the cases and amputation in 27%. At an average 30 months follow-up (9-48 months) 59.5% of the patients had remained disease-free, 37.5% had developed metastases, and 3% had developed local recurrence. The percentage of disease-free patients was higher for those treated with high doses of MTX (68% vs. 51%) and for those in whom preoperative chemotherapy had induced good necrosis (75% vs. 44%). Neither the age or sex of the patients, nor the site of the tumor type of surgery performed influenced prognosis.

Original languageEnglish
Pages (from-to)23-39
Number of pages17
JournalItalian Journal of Orthopaedics and Traumatology
Volume14
Issue number1
Publication statusPublished - 1988

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Osteosarcoma
Methotrexate
Extremities
Drug Therapy
Necrosis
Cytidine Diphosphate
Therapeutics
Clinical Protocols
Amputation
Neoplasm Metastasis
Recurrence
Pharmaceutical Preparations
Neoplasms

ASJC Scopus subject areas

  • Surgery

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Neoadjuvant chemotherapy in the treatment of osteosarcoma of the extremities : Preliminary results in 131 cases treated preoperatively with methotrexate and cisdiamminoplatinum. / Bacci, G.; Avella, M.; Capanna, R.; Boriani, S.; Dallari, D.; Galletti, S.; Giunti, A.; Madon, E.; Mancini, A.; Mercuri, M.; Orlandi, M.; Padovani, G.; Picci, P.; Sudanese, A.; Campanacci, M.

In: Italian Journal of Orthopaedics and Traumatology, Vol. 14, No. 1, 1988, p. 23-39.

Research output: Contribution to journalArticle

Bacci, G, Avella, M, Capanna, R, Boriani, S, Dallari, D, Galletti, S, Giunti, A, Madon, E, Mancini, A, Mercuri, M, Orlandi, M, Padovani, G, Picci, P, Sudanese, A & Campanacci, M 1988, 'Neoadjuvant chemotherapy in the treatment of osteosarcoma of the extremities: Preliminary results in 131 cases treated preoperatively with methotrexate and cisdiamminoplatinum', Italian Journal of Orthopaedics and Traumatology, vol. 14, no. 1, pp. 23-39.
Bacci, G. ; Avella, M. ; Capanna, R. ; Boriani, S. ; Dallari, D. ; Galletti, S. ; Giunti, A. ; Madon, E. ; Mancini, A. ; Mercuri, M. ; Orlandi, M. ; Padovani, G. ; Picci, P. ; Sudanese, A. ; Campanacci, M. / Neoadjuvant chemotherapy in the treatment of osteosarcoma of the extremities : Preliminary results in 131 cases treated preoperatively with methotrexate and cisdiamminoplatinum. In: Italian Journal of Orthopaedics and Traumatology. 1988 ; Vol. 14, No. 1. pp. 23-39.
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AU - Sudanese, A.

AU - Campanacci, M.

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