Abstract
The results of 131 cases of classic non-metastatic osteosarcoma of the extremities treated with preoperative chemotherapy, surgery and postoperative chemotherapy are reported. Preoperatively, the patients were given Methotrexate (MTX) intravenously (high and average doses) and Cisplatinum (CDP) intraarterially. For postoperative chemotherapy, the drugs and treatment protocols were based on the degree of necrosis observed (good, fair, poor). Conservative surgery was performed in 73% of the cases and amputation in 27%. At an average 30 months follow-up (9-48 months) 59.5% of the patients had remained disease-free, 37.5% had developed metastases, and 3% had developed local recurrence. The percentage of disease-free patients was higher for those treated with high doses of MTX (68% vs. 51%) and for those in whom preoperative chemotherapy had induced good necrosis (75% vs. 44%). Neither the age or sex of the patients, nor the site of the tumor type of surgery performed influenced prognosis.
| Original language | English |
|---|---|
| Pages (from-to) | 23-39 |
| Number of pages | 17 |
| Journal | Italian Journal of Orthopaedics and Traumatology |
| Volume | 14 |
| Issue number | 1 |
| Publication status | Published - 1988 |
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ASJC Scopus subject areas
- Surgery
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Neoadjuvant chemotherapy in the treatment of osteosarcoma of the extremities : Preliminary results in 131 cases treated preoperatively with methotrexate and cisdiamminoplatinum. / Bacci, G.; Avella, M.; Capanna, R.; Boriani, S.; Dallari, D.; Galletti, S.; Giunti, A.; Madon, E.; Mancini, A.; Mercuri, M.; Orlandi, M.; Padovani, G.; Picci, P.; Sudanese, A.; Campanacci, M.
In: Italian Journal of Orthopaedics and Traumatology, Vol. 14, No. 1, 1988, p. 23-39.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Neoadjuvant chemotherapy in the treatment of osteosarcoma of the extremities
T2 - Preliminary results in 131 cases treated preoperatively with methotrexate and cisdiamminoplatinum
AU - Bacci, G.
AU - Avella, M.
AU - Capanna, R.
AU - Boriani, S.
AU - Dallari, D.
AU - Galletti, S.
AU - Giunti, A.
AU - Madon, E.
AU - Mancini, A.
AU - Mercuri, M.
AU - Orlandi, M.
AU - Padovani, G.
AU - Picci, P.
AU - Sudanese, A.
AU - Campanacci, M.
PY - 1988
Y1 - 1988
N2 - The results of 131 cases of classic non-metastatic osteosarcoma of the extremities treated with preoperative chemotherapy, surgery and postoperative chemotherapy are reported. Preoperatively, the patients were given Methotrexate (MTX) intravenously (high and average doses) and Cisplatinum (CDP) intraarterially. For postoperative chemotherapy, the drugs and treatment protocols were based on the degree of necrosis observed (good, fair, poor). Conservative surgery was performed in 73% of the cases and amputation in 27%. At an average 30 months follow-up (9-48 months) 59.5% of the patients had remained disease-free, 37.5% had developed metastases, and 3% had developed local recurrence. The percentage of disease-free patients was higher for those treated with high doses of MTX (68% vs. 51%) and for those in whom preoperative chemotherapy had induced good necrosis (75% vs. 44%). Neither the age or sex of the patients, nor the site of the tumor type of surgery performed influenced prognosis.
AB - The results of 131 cases of classic non-metastatic osteosarcoma of the extremities treated with preoperative chemotherapy, surgery and postoperative chemotherapy are reported. Preoperatively, the patients were given Methotrexate (MTX) intravenously (high and average doses) and Cisplatinum (CDP) intraarterially. For postoperative chemotherapy, the drugs and treatment protocols were based on the degree of necrosis observed (good, fair, poor). Conservative surgery was performed in 73% of the cases and amputation in 27%. At an average 30 months follow-up (9-48 months) 59.5% of the patients had remained disease-free, 37.5% had developed metastases, and 3% had developed local recurrence. The percentage of disease-free patients was higher for those treated with high doses of MTX (68% vs. 51%) and for those in whom preoperative chemotherapy had induced good necrosis (75% vs. 44%). Neither the age or sex of the patients, nor the site of the tumor type of surgery performed influenced prognosis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024230460&partnerID=8YFLogxK
M3 - Article
C2 - 3235324
AN - SCOPUS:0024230460
VL - 14
SP - 23
EP - 39
JO - Italian Journal of Orthopaedics and Traumatology
JF - Italian Journal of Orthopaedics and Traumatology
SN - 0390-5489
IS - 1
ER -