Neoadjuvant combined microwave induced local hyperthermia and topical chemotherapy versus chemotherapy alone for superficial bladder cancer

R. Colombo, L. F. Da Pozzo, A. Lev, M. Freschi, G. Gallus, P. Rigatti

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Purpose: We evaluated the effectiveness of local bladder hyperthermia and intravesical chemotherapy compared to intravesical chemotherapy alone in the treatment of superficial transitional cell carcinoma. Materials and Methods: A new system designed to deliver simultaneously local bladder hyperthermia and intravesical chemotherapy has been developed at our institute. The system consists of a computerized 915 MHz, microwave source that directly heats the bladder walls (within a temperature range of 42.5 to 45.5C) using a transurethral catheter. From February 1989 to December 1993, 52 patients 44 to 81 years old (mean age 64.3) with superficial stages Ta to T1, grades 1 to 3 transitional cell carcinoma of the bladder were selected for neoadjuvant intracavitary treatment. Tumors were left intact as marker lesions. Of the patients 29 were randomly assigned to receive combined neoadjuvant intravesical chemotherapy and local hyperthermia (group 1), while 23 received intravesical chemotherapy alone (group 2). The treatment protocol included multiple sessions performed on an outpatient basis. Mitomycin C (40 mg. in 50 cc distilled water) was used for intravesical chemotherapy in both groups. All patients underwent transurethral resection of residual tumors and of all suspicious areas 7 to 10 days after completion of treatment. Only a complete response was considered for statistical analysis. Results: A pathological complete response was documented in 19 cases (66%) in group 1 and 5 (22%) in group 2 (chi-square p

Original languageEnglish
Pages (from-to)1227-1232
Number of pages6
JournalJournal of Urology
Volume155
Issue number4
DOIs
Publication statusPublished - Apr 1996

Fingerprint

Induced Hyperthermia
Microwaves
Urinary Bladder Neoplasms
Drug Therapy
Urinary Bladder
Transitional Cell Carcinoma
Neoadjuvant Therapy
Residual Neoplasm
Mitomycin
Clinical Protocols
Outpatients
Catheters
Hot Temperature
Temperature
Water
Therapeutics
Neoplasms

Keywords

  • bladder neoplasms
  • carcinoma, transitional cell
  • hyperthermia, induced

ASJC Scopus subject areas

  • Urology

Cite this

Neoadjuvant combined microwave induced local hyperthermia and topical chemotherapy versus chemotherapy alone for superficial bladder cancer. / Colombo, R.; Da Pozzo, L. F.; Lev, A.; Freschi, M.; Gallus, G.; Rigatti, P.

In: Journal of Urology, Vol. 155, No. 4, 04.1996, p. 1227-1232.

Research output: Contribution to journalArticle

Colombo, R. ; Da Pozzo, L. F. ; Lev, A. ; Freschi, M. ; Gallus, G. ; Rigatti, P. / Neoadjuvant combined microwave induced local hyperthermia and topical chemotherapy versus chemotherapy alone for superficial bladder cancer. In: Journal of Urology. 1996 ; Vol. 155, No. 4. pp. 1227-1232.
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