IMMUNOTERAPIA NEOADIUVANTE CON INTERLEUCHINA-2 IN PAZIENTI AFFETTI DA CARCINOMA VESCICALE DI BASSO STADIO. ASPETTI CLINICI ED IMMUNOLOGICI

Translated title of the contribution: Neoadjuvant immunotherapy with interleukin-2 in patients with early-stage bladder carcinoma. Clinical and immunological aspects

L. Miano, A. Tubaro, C. Vicentini, P. Galassi, P. C. Bossola, F. Scapellato, F. Velotti, A. Pettinato, S. Morrone, T. Napolitano, A. Santoni, A. Stoppacciaro, L. Ruco, F. Franks, P. Palmer, C. Pourreau

Research output: Contribution to journalArticle

Abstract

Between June 1988 and July 1989, 10 patients affected by transitional cell carcinoma of the bladder (Ta-T1, N0, M0; G1-2) were enrolled in this clinical trial. A dose escalating scheme from 18 x 103 to 18 x 106 IU/m2/day was used in subgroups of 3 patients each. Two five-day cycles of rIL-2, with a 48-hour interruption in between, were administered. Continuous intra-arterial infusion was performed through a 5 Fr angiographic catheter in the hypogastric artery. Transurethral resection of the bladder tumor was performed 4 days after the end of the 2nd cycle. Two complete and two partial responses were observed out of 10 treated patients. In 6 cases, no modification of the tumor was observed. Immunological monitoring of peripheral blood lymphocytes demonstrated activation of T lymphocyte subpopulations and increase of NK, LAK and ADCC cytotoxicity in some patients.

Translated title of the contributionNeoadjuvant immunotherapy with interleukin-2 in patients with early-stage bladder carcinoma. Clinical and immunological aspects
Original languageItalian
Pages (from-to)63-68
Number of pages6
JournalActa Urologica Italica
Volume4
Issue number6 SUPPL. 1
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Neoadjuvant immunotherapy with interleukin-2 in patients with early-stage bladder carcinoma. Clinical and immunological aspects'. Together they form a unique fingerprint.

  • Cite this

    Miano, L., Tubaro, A., Vicentini, C., Galassi, P., Bossola, P. C., Scapellato, F., Velotti, F., Pettinato, A., Morrone, S., Napolitano, T., Santoni, A., Stoppacciaro, A., Ruco, L., Franks, F., Palmer, P., & Pourreau, C. (1990). IMMUNOTERAPIA NEOADIUVANTE CON INTERLEUCHINA-2 IN PAZIENTI AFFETTI DA CARCINOMA VESCICALE DI BASSO STADIO. ASPETTI CLINICI ED IMMUNOLOGICI. Acta Urologica Italica, 4(6 SUPPL. 1), 63-68.