Radioterapia neoadiuvante associata ad oxaliplatino e 5-fluorouracile in pazienti affetti da tumore rettale localmente avanzato: l'esperienza di un singolo centro

Translated title of the contribution: Neoadjuvant oxaliplatin and 5-fluorouracil with concurrent radiotherapy in patients with locally advanced rectal cancer: A singleinstitution experience

D. Greto, F. Paiar, C. Saieva, A. Galardi, M. Mangoni, L. Livi, B. Agresti, D. Franceschini, P. Bonomo, V. Scotti, B. Detti, F. Tonelli, A. Valeri, L. Messerini, G. Biti

Research output: Contribution to journalArticle

Abstract

Purpose: The aim of this study was to evaluate the rate of pathological response (PR), disease control and safety of neoadjuvant chemotherapy using oxaliplatin (OX) and 5-fluorouracil (5-FU) with concurrent radiotherapy for treating locally advanced rectal cancer. Materials and methods: Between November 2002 and December 2010, 90 patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy (CRT) were retrospectively analysed. All patients underwent preoperative radiotherapy (45 Gy in 1.8-Gy fractions) with concurrent OX (80 mg/m2 i.v., day 1) and a 120-h continuous infusion of 5-FU (1,000 mg/m2 per day). Surgery was performed within 6 weeks after completion of CRT treatment. Results: Complete pathological response was obtained in six patients (6.7%), and 39 (43.3%) had their disease downstaged. The median follow-up period was 4.7 years (6 months to 9 years). Local recurrence occurred in two patients (2.2%), one of whom developed also liver metastases. Distant metastases not associated with local relapse occurred in 23 (25.6%) patients. Overall (OS) and disease-free (DFS) survival were 62.9% and 52.8%, respectively. CRT was well tolerated, with only one grade 3 (1.2%) haematological toxicity (neutropaenia). Conclusions: Neoadjuvant systemic chemotherapy based on OX and 5-UC associated with radiotherapy is well tolerated, with good results in terms of pathological response, disease control and survival, in rectal cancer patients.

Translated title of the contributionNeoadjuvant oxaliplatin and 5-fluorouracil with concurrent radiotherapy in patients with locally advanced rectal cancer: A singleinstitution experience
Original languageItalian
Pages (from-to)570-582
Number of pages13
JournalRadiologia Medica
Volume118
Issue number4
DOIs
Publication statusPublished - Jun 2013

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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    Greto, D., Paiar, F., Saieva, C., Galardi, A., Mangoni, M., Livi, L., Agresti, B., Franceschini, D., Bonomo, P., Scotti, V., Detti, B., Tonelli, F., Valeri, A., Messerini, L., & Biti, G. (2013). Radioterapia neoadiuvante associata ad oxaliplatino e 5-fluorouracile in pazienti affetti da tumore rettale localmente avanzato: l'esperienza di un singolo centro. Radiologia Medica, 118(4), 570-582. https://doi.org/10.1007/s11547-012-0909-4