TY - JOUR
T1 - Neoadjuvant therapy in locally advanced breast cancer
T2 - 99mTc-MIBI mammoscintigraphy is not a reliable technique to predict therapy response
AU - Travaini, Laura Lavinia
AU - Baio, Silvia Melania
AU - Cremonesi, Marta
AU - Cicco, Concetta De
AU - Ferrari, Mahila
AU - Trifirò, Giuseppe
AU - Prisco, Gennaro
AU - Viale, Giuseppe
AU - Colleoni, Marco Angelo
AU - Radice, Davide
AU - Sivolapenko, Gregory B.
AU - Paganelli, Giovanni
PY - 2007/6
Y1 - 2007/6
N2 - Mammoscintigraphy (MMS) has been indicated as a useful tool in predicting response to therapy in cancer. However, contrasting results have been reported in the literature for breast cancer patients. The aim of this study was to explore the role of MMS in locally advanced breast cancer (LABC) patients. Fifty-one patients affected by LABC and scheduled for neoadjuvant therapy were enrolled. Breast tumor status was evaluated at baseline, during therapy and at the completion of therapy by radiological techniques and by MMS. Pre-therapy (MMS1) and post-therapy MIBI (2-methoxyisobutilysonitrile) images (MMS2-3) were analyzed. MMS1 was performed in all pts, 41 carried out MMS2 and 27 had MMS3. Tumor uptake and washout in MMS1 did not show any correlation with the therapy response. The absence of any association between tumor uptake and washout with respect to therapy response suggests that MMS is not a reliable technique to predict therapy response in LABC.
AB - Mammoscintigraphy (MMS) has been indicated as a useful tool in predicting response to therapy in cancer. However, contrasting results have been reported in the literature for breast cancer patients. The aim of this study was to explore the role of MMS in locally advanced breast cancer (LABC) patients. Fifty-one patients affected by LABC and scheduled for neoadjuvant therapy were enrolled. Breast tumor status was evaluated at baseline, during therapy and at the completion of therapy by radiological techniques and by MMS. Pre-therapy (MMS1) and post-therapy MIBI (2-methoxyisobutilysonitrile) images (MMS2-3) were analyzed. MMS1 was performed in all pts, 41 carried out MMS2 and 27 had MMS3. Tumor uptake and washout in MMS1 did not show any correlation with the therapy response. The absence of any association between tumor uptake and washout with respect to therapy response suggests that MMS is not a reliable technique to predict therapy response in LABC.
KW - Adjuvant therapy
KW - Breast tumor
KW - Mammoscintigraphy
KW - Multidrug resistance
KW - Therapy response
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U2 - 10.1016/j.breast.2006.12.009
DO - 10.1016/j.breast.2006.12.009
M3 - Article
C2 - 17291755
AN - SCOPUS:34249099083
VL - 16
SP - 262
EP - 270
JO - Breast
JF - Breast
SN - 0960-9776
IS - 3
ER -