Neoadjuvant treatment for resectable locally advanced gastric cancer

Domenico D'Ugo, Alberto Biondi, Ferdinando Cananzi

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter briefly reviews recent developments in pre-operative therapies for gastric carcinoma, stressing their safety and efficacy. The data and studies discussed in the following were obtained from PubMed, using the search terms pre-operative chemotherapy, pre-operative radiotherapy, pre-operative chemoradiotherapy, neoadjuvant treatment, and gastric cancer. Only papers published in English from January 1970 through January 2010 were taken into consideration. Studies conducted over the last 20 years have progressed from the first pioneering chemotherapies for patients with non-resectable disease (induction therapy) to the most recent phase III trials on neoadjuvant therapies for resectable gastric neoplasms. There have also been several clinical trials examining pre-operative chemotherapy in the management of gastric cancer. While further evidence on the definitive role of neoadjuvant therapy is still needed, the most recent results of treatment using a multimodal approach to gastric adenocarcinoma are encouraging. In fact, most pre-operative multimodal regimens increase the likelihood that postponed tumor resection can still fulfill all the requirements of a true R0 resection.

Original languageEnglish
Title of host publicationSurgery in the Multimodal Management of Gastric Cancer
PublisherSpringer-Verlag Italia s.r.l.
Number of pages12
ISBN (Print)9788847023185, 8847023173, 9788847023178
Publication statusPublished - Nov 1 2012


  • Chemoradiotherapy
  • Chemotherapy
  • Down-staging
  • Metabolic response
  • Neoadjuvant chemotherapy
  • Pathologic response
  • Pre-operative chemotherapy, Peri-operative chemotherapy
  • R0 resection
  • Radiotherapy

ASJC Scopus subject areas

  • Medicine(all)


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