Neocortical RELN promoter methylation increases significantly after puberty

Carla Lintas, Antonio M. Persico

Research output: Contribution to journalArticlepeer-review

Abstract

Reelin plays a pivotal role in neurodevelopment. Excessive RELN promoter methylation and/or decreased RELN gene expression have been described in schizophrenia and autism. We assessed RELN promoter methylation in post-mortem temporocortical tissue (Brodmann Area 41/42) of three prepuberal and six postpuberal normal individuals. The former display very little or no methylation, whereas most postpuberal individuals are heavily methylated, especially at CpG positions located between - 131 and - 98bp (prepuberal vs. postpuberal, P

Original languageEnglish
Pages (from-to)114-118
Number of pages5
JournalNeuroReport
Volume21
Issue number2
DOIs
Publication statusPublished - 2010

Keywords

  • Autism
  • DNA methylation
  • Epigenetics
  • Neocortex
  • Neurodevelopment
  • Pervasive developmental disorders
  • Reelin
  • RELN
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

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