TY - JOUR
T1 - Neonatal basal forebrain cholinergic hypofunction affects ultrasonic vocalizations and fear conditioning responses in preweaning rats
AU - Ricceri, Laura
AU - Cutuli, Debora
AU - Venerosi, Aldina
AU - Scattoni, Maria Luisa
AU - Calamandrei, Gemma
PY - 2007/10/1
Y1 - 2007/10/1
N2 - The present study investigated the effects of intracebroventricular injections of 192 IgG-saporin in 7-day-old rats on (i) ultrasound vocalizations (USVs) on postnatal day (pnd) 13 following isolation and reunion with the mother and (ii) fear conditioning on pnd 18-19 recording both freezing and other behavioural responses as well as USVs. On pnd 13 lesioned and control pups showed comparable USV baseline values; a brief reunion with the mother induced a significant increase in USVs in all rats (maternal potentiation). On pnd 18, during the fear conditioning training, 192 IgG-saporin rats emitted a lower number of USVs. On pnd 19 all rats showed a stronger conditioned response (with full inhibition of locomotion) to auditory than to contextual cues. Surprisingly, lesioned rats showed a stronger fear-conditioned response to contextual cues than controls. These results suggest that early selective removal of the cholinergic basal forebrain paradoxically enhances hippocampally dependent fear-conditioned responses on pnd 19.
AB - The present study investigated the effects of intracebroventricular injections of 192 IgG-saporin in 7-day-old rats on (i) ultrasound vocalizations (USVs) on postnatal day (pnd) 13 following isolation and reunion with the mother and (ii) fear conditioning on pnd 18-19 recording both freezing and other behavioural responses as well as USVs. On pnd 13 lesioned and control pups showed comparable USV baseline values; a brief reunion with the mother induced a significant increase in USVs in all rats (maternal potentiation). On pnd 18, during the fear conditioning training, 192 IgG-saporin rats emitted a lower number of USVs. On pnd 19 all rats showed a stronger conditioned response (with full inhibition of locomotion) to auditory than to contextual cues. Surprisingly, lesioned rats showed a stronger fear-conditioned response to contextual cues than controls. These results suggest that early selective removal of the cholinergic basal forebrain paradoxically enhances hippocampally dependent fear-conditioned responses on pnd 19.
KW - 192 IgG-saporin
KW - ChAT
KW - Cholinergic development
KW - Maternal potentiation
KW - Ultrasounds
UR - http://www.scopus.com/inward/record.url?scp=34547882744&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547882744&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2007.05.035
DO - 10.1016/j.bbr.2007.05.035
M3 - Article
C2 - 17624452
AN - SCOPUS:34547882744
VL - 183
SP - 111
EP - 117
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
IS - 1
ER -