Neonatal Cerebral Infarction and Neuromotor Outcome at School Age

Eugenio Mercuri, Anna Barnett, Mary Rutherford, Andrea Guzzetta, Leena Haataja, Giovanni Cioni, Frances Cowan, Lilly Dubowitz

Research output: Contribution to journalArticle

Abstract

Objective. The aim of this study was to assess neuromotor function at school age in children who had cerebral infarction on neonatal magnetic resonance imaging (MRI). Design. Twenty-two children with evidence of cerebral infarction on neonatal brain MRI (18 with arterial infarction and 4 with border-zone lesions) were assessed at school age with a structured neurologic examination and the Movement Assessment Battery for Children, a battery of tests designed to assess motor function. Results. Of the 22 children, 6 (30%) had hemiplegia and a further 7 (30%) showed some neuromotor abnormality such as asymmetry on the neurologic examination (n = 4) or poor scores on the neuromotor test without any sign of asymmetry (n = 3). The remaining 9 children had a normal motor outcome. Hemiplegia was found only in children who had concomitant involvement of hemisphere, internal capsule, and basal ganglia on brain MRI. Children with involvement of the internal capsule, associated either with basal ganglia or hemispheric lesions, did not show hemiplegia but still had motor difficulties. Conclusions. Our results suggest that although hemiplegia occurs in a relatively small proportion of children with neonatal cerebral infarction, other signs of neuromotor impairment can be present, and these become more obvious at school age when a more specific assessment can be performed. These results also suggest that the involvement of the internal capsule on neonatal MRI can predict the presence of these abnormalities.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalPediatrics
Volume113
Issue number1 I
DOIs
Publication statusPublished - Jan 2004

Fingerprint

Cerebral Infarction
Hemiplegia
Internal Capsule
Magnetic Resonance Imaging
Neurologic Examination
Basal Ganglia
Brain
Infarction

Keywords

  • Hemiplegia
  • Mov ABC
  • MRI
  • Neonatal cerebral infarction

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Mercuri, E., Barnett, A., Rutherford, M., Guzzetta, A., Haataja, L., Cioni, G., ... Dubowitz, L. (2004). Neonatal Cerebral Infarction and Neuromotor Outcome at School Age. Pediatrics, 113(1 I), 95-100. https://doi.org/10.1542/peds.113.1.95

Neonatal Cerebral Infarction and Neuromotor Outcome at School Age. / Mercuri, Eugenio; Barnett, Anna; Rutherford, Mary; Guzzetta, Andrea; Haataja, Leena; Cioni, Giovanni; Cowan, Frances; Dubowitz, Lilly.

In: Pediatrics, Vol. 113, No. 1 I, 01.2004, p. 95-100.

Research output: Contribution to journalArticle

Mercuri, E, Barnett, A, Rutherford, M, Guzzetta, A, Haataja, L, Cioni, G, Cowan, F & Dubowitz, L 2004, 'Neonatal Cerebral Infarction and Neuromotor Outcome at School Age', Pediatrics, vol. 113, no. 1 I, pp. 95-100. https://doi.org/10.1542/peds.113.1.95
Mercuri, Eugenio ; Barnett, Anna ; Rutherford, Mary ; Guzzetta, Andrea ; Haataja, Leena ; Cioni, Giovanni ; Cowan, Frances ; Dubowitz, Lilly. / Neonatal Cerebral Infarction and Neuromotor Outcome at School Age. In: Pediatrics. 2004 ; Vol. 113, No. 1 I. pp. 95-100.
@article{a5089b5c16be4e439b3c775fabc64c3d,
title = "Neonatal Cerebral Infarction and Neuromotor Outcome at School Age",
abstract = "Objective. The aim of this study was to assess neuromotor function at school age in children who had cerebral infarction on neonatal magnetic resonance imaging (MRI). Design. Twenty-two children with evidence of cerebral infarction on neonatal brain MRI (18 with arterial infarction and 4 with border-zone lesions) were assessed at school age with a structured neurologic examination and the Movement Assessment Battery for Children, a battery of tests designed to assess motor function. Results. Of the 22 children, 6 (30{\%}) had hemiplegia and a further 7 (30{\%}) showed some neuromotor abnormality such as asymmetry on the neurologic examination (n = 4) or poor scores on the neuromotor test without any sign of asymmetry (n = 3). The remaining 9 children had a normal motor outcome. Hemiplegia was found only in children who had concomitant involvement of hemisphere, internal capsule, and basal ganglia on brain MRI. Children with involvement of the internal capsule, associated either with basal ganglia or hemispheric lesions, did not show hemiplegia but still had motor difficulties. Conclusions. Our results suggest that although hemiplegia occurs in a relatively small proportion of children with neonatal cerebral infarction, other signs of neuromotor impairment can be present, and these become more obvious at school age when a more specific assessment can be performed. These results also suggest that the involvement of the internal capsule on neonatal MRI can predict the presence of these abnormalities.",
keywords = "Hemiplegia, Mov ABC, MRI, Neonatal cerebral infarction",
author = "Eugenio Mercuri and Anna Barnett and Mary Rutherford and Andrea Guzzetta and Leena Haataja and Giovanni Cioni and Frances Cowan and Lilly Dubowitz",
year = "2004",
month = "1",
doi = "10.1542/peds.113.1.95",
language = "English",
volume = "113",
pages = "95--100",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "1 I",

}

TY - JOUR

T1 - Neonatal Cerebral Infarction and Neuromotor Outcome at School Age

AU - Mercuri, Eugenio

AU - Barnett, Anna

AU - Rutherford, Mary

AU - Guzzetta, Andrea

AU - Haataja, Leena

AU - Cioni, Giovanni

AU - Cowan, Frances

AU - Dubowitz, Lilly

PY - 2004/1

Y1 - 2004/1

N2 - Objective. The aim of this study was to assess neuromotor function at school age in children who had cerebral infarction on neonatal magnetic resonance imaging (MRI). Design. Twenty-two children with evidence of cerebral infarction on neonatal brain MRI (18 with arterial infarction and 4 with border-zone lesions) were assessed at school age with a structured neurologic examination and the Movement Assessment Battery for Children, a battery of tests designed to assess motor function. Results. Of the 22 children, 6 (30%) had hemiplegia and a further 7 (30%) showed some neuromotor abnormality such as asymmetry on the neurologic examination (n = 4) or poor scores on the neuromotor test without any sign of asymmetry (n = 3). The remaining 9 children had a normal motor outcome. Hemiplegia was found only in children who had concomitant involvement of hemisphere, internal capsule, and basal ganglia on brain MRI. Children with involvement of the internal capsule, associated either with basal ganglia or hemispheric lesions, did not show hemiplegia but still had motor difficulties. Conclusions. Our results suggest that although hemiplegia occurs in a relatively small proportion of children with neonatal cerebral infarction, other signs of neuromotor impairment can be present, and these become more obvious at school age when a more specific assessment can be performed. These results also suggest that the involvement of the internal capsule on neonatal MRI can predict the presence of these abnormalities.

AB - Objective. The aim of this study was to assess neuromotor function at school age in children who had cerebral infarction on neonatal magnetic resonance imaging (MRI). Design. Twenty-two children with evidence of cerebral infarction on neonatal brain MRI (18 with arterial infarction and 4 with border-zone lesions) were assessed at school age with a structured neurologic examination and the Movement Assessment Battery for Children, a battery of tests designed to assess motor function. Results. Of the 22 children, 6 (30%) had hemiplegia and a further 7 (30%) showed some neuromotor abnormality such as asymmetry on the neurologic examination (n = 4) or poor scores on the neuromotor test without any sign of asymmetry (n = 3). The remaining 9 children had a normal motor outcome. Hemiplegia was found only in children who had concomitant involvement of hemisphere, internal capsule, and basal ganglia on brain MRI. Children with involvement of the internal capsule, associated either with basal ganglia or hemispheric lesions, did not show hemiplegia but still had motor difficulties. Conclusions. Our results suggest that although hemiplegia occurs in a relatively small proportion of children with neonatal cerebral infarction, other signs of neuromotor impairment can be present, and these become more obvious at school age when a more specific assessment can be performed. These results also suggest that the involvement of the internal capsule on neonatal MRI can predict the presence of these abnormalities.

KW - Hemiplegia

KW - Mov ABC

KW - MRI

KW - Neonatal cerebral infarction

UR - http://www.scopus.com/inward/record.url?scp=0347986895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347986895&partnerID=8YFLogxK

U2 - 10.1542/peds.113.1.95

DO - 10.1542/peds.113.1.95

M3 - Article

C2 - 14702455

AN - SCOPUS:0347986895

VL - 113

SP - 95

EP - 100

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 1 I

ER -