Neonatal cutaneous disseminated aspergillosis in a preterm extremely-low-birth-weight infant with favourable outcome at 3-year follow-up: A case report

P. Manzoni, S. Rizzollo, C. Monetti, C. Carbonara, C. Priolo, E. Mastretta, L. Barberis, P. Galletto, P. Cigna, M. L. Leonessa, U. Sala, G. Gomirato, M. Mostert, M. Stronati, G. Ruffinazzi, C. Tzialla, E. Jacqz-Aigrain, F. Kaguelidou, D. Farina

Research output: Contribution to journalArticlepeer-review

Abstract

Invasive disseminated neonatal aspergillosis is an uncommon disease, with only scattered reports in literature in the last few years. Here we report on a 25-week gestational age, 730 g at birth preterm female infant who developed on day-of-life 10 multiple cutaneous exhulcerative lesions in her right arm, trunk and abdomen. Early recognition and diagnosis of these lesions as a due to cutaneous initial symptom of cutaneous disseminated aspergillosis, as well as prompt treatment with Liposomal amphotericin B + Itraconazole, secured successful recovery from the systemic infection. Skin lesions healed without any surgical treatment. The infant was discharged in good health. Long-term follow-up at three years of age revealed normality of all neurodevelopmental and cognitive parameters. To our knowledge, this is one of the very few cases of survival, free from sequelae, for a preterm infant affected by neonatal cutaneous disseminated aspergillosis.

Original languageEnglish
JournalEarly Human Development
Volume88
Issue numberSUPPL.2
DOIs
Publication statusPublished - May 2012

Keywords

  • Aspergillosis
  • Cutaneous disseminated
  • Infection
  • Liposomal amphotericin b
  • Preterm neonates

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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