Neonatal diagnosis of tuberous sclerosis

L. A. Ramenghi, A. Verrotti, S. Domizio, C. Di Rocco, G. Morgese, G. Sabatino

Research output: Contribution to journalArticlepeer-review

Abstract

Intracranial tumors are rare in the neonatal period, and generally the most common histological types are astrocytoma, medulloblastoma, choroid plexus papilloma and neuroectodermal tumors. The early diagnosis of these tumors is often very difficult. The authors report a case of a full-term newborn who presented with opisthotonus. A subependymal mass was detected by cerebral ultrasonography, and when the child was 1 month of age depigmentations appeared on the trunk and on the right leg, confirming the suspicion of tuberous sclerosis. At 3 months of age the child suffered infantile spasm with hypsarrhythmia. The developmental delay, the marked progressive neurological deterioration and the daily seizures suggested surgical resection. Histologic studies showed a subependymal giant cell astrocytoma such as typically occurs in tuberous sclerosis.

Original languageEnglish
Pages (from-to)121-123
Number of pages3
JournalChild's Nervous System
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 1996

Keywords

  • Astrocytoma
  • Newborn
  • Subependymal giant cell
  • Tuberous sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

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