Neonatal lupus: Fetal myocarditis progressing to atrioventricular block in triplets

V. Fesslova, S. Mannarino, P. Salice, C. Boschetto, L. Trespidi, B. Acaia, F. Mosca, R. Cimaz, P. L. Meroni

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of neonatal lupus syndrome (NLS) in an in vitro fertilization induced triplet pregnancy. Echocardiographic signs of myocarditis were evident at the 21st week of gestation (w.g.) in twin I, with a subsequent development of a complete atrioventricular (AV) block at the 25th w.g.; twin III also displayed echocardiographic signs of myocarditis at the same time. Treatment with dexamethasone (4mg/day) was started at the 25th w.g. A complete echocardiographic regression of the myocarditis signs was achieved, while AV block was unaffected. Caesarian section was performed at the 31.5 w.g. after a premature rupture of the membranes. Complete AV block was confirmed in twin I with a heart rate of 51 beats/min that required a pacemaker implant 40 days after. Twin III developed a first-degree AV block that switched to a periodic second-degree block later, while twin II displayed only liver enzyme abnormalities.

Original languageEnglish
Pages (from-to)775-778
Number of pages4
JournalLupus
Volume12
Issue number10
DOIs
Publication statusPublished - 2003

Keywords

  • Anti-Ro antibodies
  • Congenital heart block
  • Fetal echocardiography
  • Neonatal lupus

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Fingerprint Dive into the research topics of 'Neonatal lupus: Fetal myocarditis progressing to atrioventricular block in triplets'. Together they form a unique fingerprint.

Cite this