Neonatal neurological examination in infants with hypoxic ischaemic encephalopathy: Correlation with MRI findings

Eugenia Mercuri, A. Guzzetta, Leena Haataja, Frances Cowan, Mary Rutherford, Serena Counsell, Maria Papadimitriou, G. Cioni, Lilly Dubowitz

Research output: Contribution to journalArticle

Abstract

Neurological examination and magnetic resonance imaging were performed in the neonatal period in 58 full-term infants who presented with hypoxic-ischaemic encephalopathy. The aim of this study was to evaluate the patterns of neurological abnormalities and their correlation to brain lesions on MRI. The prognostic value of the neurological examination performed at different times in the neonatal period was also evaluated. Our results showed that specific clinical patterns can be observed in infants with HIE and these can be related to the pattern of lesion on brain MRI. In particular, while infants with normal MRI or minimal changes tend to show only minor tone abnormalities after the first week of life, infants with more severe lesions such as basal ganglia lesions show persistent and diffuse neurological abnormalities. Infants with white matter changes but intact basal ganglia show a different clinical pattern with improved sucking reflex and behaviour and less severe tone abnormalities. Our results also suggested that the neurological examination performed after the second week of life is a reliable indicator of outcome in these infants.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalNeuropediatrics
Volume30
Issue number2
Publication statusPublished - Apr 1999

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Brain Hypoxia-Ischemia
Neurologic Examination
Basal Ganglia
Sucking Behavior
Brain
Reflex
Magnetic Resonance Imaging

Keywords

  • HIE
  • MRI
  • Neurological examination
  • Newborn

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Mercuri, E., Guzzetta, A., Haataja, L., Cowan, F., Rutherford, M., Counsell, S., ... Dubowitz, L. (1999). Neonatal neurological examination in infants with hypoxic ischaemic encephalopathy: Correlation with MRI findings. Neuropediatrics, 30(2), 83-89.

Neonatal neurological examination in infants with hypoxic ischaemic encephalopathy : Correlation with MRI findings. / Mercuri, Eugenia; Guzzetta, A.; Haataja, Leena; Cowan, Frances; Rutherford, Mary; Counsell, Serena; Papadimitriou, Maria; Cioni, G.; Dubowitz, Lilly.

In: Neuropediatrics, Vol. 30, No. 2, 04.1999, p. 83-89.

Research output: Contribution to journalArticle

Mercuri, E, Guzzetta, A, Haataja, L, Cowan, F, Rutherford, M, Counsell, S, Papadimitriou, M, Cioni, G & Dubowitz, L 1999, 'Neonatal neurological examination in infants with hypoxic ischaemic encephalopathy: Correlation with MRI findings', Neuropediatrics, vol. 30, no. 2, pp. 83-89.
Mercuri, Eugenia ; Guzzetta, A. ; Haataja, Leena ; Cowan, Frances ; Rutherford, Mary ; Counsell, Serena ; Papadimitriou, Maria ; Cioni, G. ; Dubowitz, Lilly. / Neonatal neurological examination in infants with hypoxic ischaemic encephalopathy : Correlation with MRI findings. In: Neuropediatrics. 1999 ; Vol. 30, No. 2. pp. 83-89.
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