Neonatal Screening and Nutrition/Growth in Cystic Fibrosis: A Review

Donatello Salvatore

Research output: Chapter in Book/Report/Conference proceedingChapter


Optimization of growth and nutritional status is essential for effective treatment of individuals with cystic fibrosis (CF). Several studies show the relationship between growth and nutritional indices in early life with pulmonary function until the age of 8-10. years, giving indirect evidence that children with CF diagnosed by newborn screening and then subjected to early nutritional treatment may have an advantage on lung function in childhood. Evaluating the direct relationship between screening and benefits on growth/nutrition, the results of the controlled studies derived from the Wisconsin CF Screening Project show that screened children have improvement of all anthropometric parameters that lasts beyond infancy. Moreover, studies from national registries and cohort studies consistently show benefits of screening on nutritional status, at least in childhood. Early initiation of pancreatic enzyme replacement therapy and vitamin supplementation may result in other benefits: an analysis of the cognitive score supports the hypothesis that a prolonged deficiency of vitamin E affects cognitive status; therefore, the early introduction of vitamins could have favorable implications in screened children even in this clinical aspect.

Original languageEnglish
Title of host publicationDiet and Exercise in Cystic Fibrosis
PublisherElsevier Inc.
Number of pages7
ISBN (Print)9780128005880, 9780128000519
Publication statusPublished - Aug 12 2014


  • Cystic fibrosis
  • Growth
  • Newborn screening
  • Nutrition
  • Pancreatic insufficiency
  • Vitamin

ASJC Scopus subject areas

  • Medicine(all)


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