Neonatal soft tissue sarcomas

Andrea Ferrari, Daniel Orbach, Iyad Sultan, Michela Casanova, Gianni Bisogno

Research output: Contribution to journalArticlepeer-review


Soft tissue tumors in very young children pose diagnostic and therapeutic challenges. Vascular tumors are the most prevalent soft tissue neoplasms in the neonatal period. They are generally benign tumors, but may exhibit aggressive behaviour and cause life-threatening complications. Fibroblastic tumors of intermediate prognosis, more prevalent in very young children (especially infantile fibrosarcoma), are locally aggressive. Since metastases are unusual in this group of tumors, complete surgical resection is generally curative. However, these tumors often present a therapeutic challenge because of the location which makes complete surgical resection difficult. Among the malignant soft tissue tumors, rhabdomyosarcoma is most frequent. It is an aggressive high-grade tumor, with local invasiveness and a propensity to metastasize. These tumors respond to chemotherapy and radiotherapy. Neonates with rhabdomyosarcoma seem to have a worse prognosis than in older age groups. This may be a result of inappropriate dosing of chemotherapeutic agents and decreased use of radiation therapy among other factors.

Original languageEnglish
Pages (from-to)231-238
Number of pages8
JournalSeminars in Fetal and Neonatal Medicine
Issue number4
Publication statusPublished - Aug 2012


  • Infantile fibrosarcoma
  • Infants
  • Neonatal
  • Rhabdomyosarcoma
  • Soft tissue sarcomas
  • Vascular tumors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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