Abstract
Thromboembolic disease is a complex disorder with a multifactorial aetiology and a severe outcome. In newborns and children it may be missed or diagnosed late, thus worsening the prognosis. The neonatal disease is different from the disorder affecting older children and adults. However, scant epidemiological data and few randomised clinical trials regarding paediatric patients are available, and treatment recommendations are largely based on adult guidelines. Younger patients then have several decades over which they will suffer from the complications of thrombosis and risk of a new thrombotic episode. Current knowledge about neonatal thromboembolic disease and its prevention is reviewed here along with maternal, foetal, neonatal, pharmacological, environmental, lifestyle and occupational contributing factors. Additional data are urgently needed to improve diagnostic and therapeutic strategies and patient outcomes.
| Original language | English |
|---|---|
| Pages (from-to) | 499-509 |
| Number of pages | 11 |
| Journal | Current Vascular Pharmacology |
| Volume | 16 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jan 1 2018 |
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Keywords
- Disease management
- Heparin
- Neonate
- Risk
- Thrombolysis
- Thrombophilia
- Thrombosis
- Treatment
ASJC Scopus subject areas
- Pharmacology
- Cardiology and Cardiovascular Medicine
Cite this
Neonatal systemic thrombosis : An updated overview. / Conti, Gea Oliveri; Molinari, Angelo Claudio; Signorelli, Salvatore Santo; Ruggieri, Martino; Grasso, Alfina; Ferrante, Margherita.
In: Current Vascular Pharmacology, Vol. 16, No. 5, 01.01.2018, p. 499-509.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Neonatal systemic thrombosis
T2 - An updated overview
AU - Conti, Gea Oliveri
AU - Molinari, Angelo Claudio
AU - Signorelli, Salvatore Santo
AU - Ruggieri, Martino
AU - Grasso, Alfina
AU - Ferrante, Margherita
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Thromboembolic disease is a complex disorder with a multifactorial aetiology and a severe outcome. In newborns and children it may be missed or diagnosed late, thus worsening the prognosis. The neonatal disease is different from the disorder affecting older children and adults. However, scant epidemiological data and few randomised clinical trials regarding paediatric patients are available, and treatment recommendations are largely based on adult guidelines. Younger patients then have several decades over which they will suffer from the complications of thrombosis and risk of a new thrombotic episode. Current knowledge about neonatal thromboembolic disease and its prevention is reviewed here along with maternal, foetal, neonatal, pharmacological, environmental, lifestyle and occupational contributing factors. Additional data are urgently needed to improve diagnostic and therapeutic strategies and patient outcomes.
AB - Thromboembolic disease is a complex disorder with a multifactorial aetiology and a severe outcome. In newborns and children it may be missed or diagnosed late, thus worsening the prognosis. The neonatal disease is different from the disorder affecting older children and adults. However, scant epidemiological data and few randomised clinical trials regarding paediatric patients are available, and treatment recommendations are largely based on adult guidelines. Younger patients then have several decades over which they will suffer from the complications of thrombosis and risk of a new thrombotic episode. Current knowledge about neonatal thromboembolic disease and its prevention is reviewed here along with maternal, foetal, neonatal, pharmacological, environmental, lifestyle and occupational contributing factors. Additional data are urgently needed to improve diagnostic and therapeutic strategies and patient outcomes.
KW - Disease management
KW - Heparin
KW - Neonate
KW - Risk
KW - Thrombolysis
KW - Thrombophilia
KW - Thrombosis
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=85049945838&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049945838&partnerID=8YFLogxK
U2 - 10.2174/1570161116666180117101445
DO - 10.2174/1570161116666180117101445
M3 - Review article
C2 - 29345589
AN - SCOPUS:85049945838
VL - 16
SP - 499
EP - 509
JO - Current Vascular Pharmacology
JF - Current Vascular Pharmacology
SN - 1570-1611
IS - 5
ER -