Neonatal thyroid function in seveso 25 years after maternal exposure to dioxin

Andrea Baccarelli, Sara M. Giacomini, Carlo Corbetta, Maria Teresa Landi, Matteo Bonzini, Dario Consonni, Paolo Grillo, Donald G. Patterson, Angela C. Pesatori, Pier Alberto Bertazzi

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Abstract

Background: Neonatal hypothyroidism has been associated in animal models with maternal exposure to several environmental contaminants; however, evidence for such an association in humans is inconsistent. We evaluated whether maternal exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a persistent and widespread toxic environmental contaminant, is associated with modified neonatal thyroid function in a large, highly exposed population in Seveso, Italy. Methods and Findings: Between 1994 and 2005, in individuals exposed to TCDD after the 1976 Seveso accident we conducted: (i) a residence-based population study on 1,014 children born to the 1,772 women of reproductive age in the most contaminated zones (A, very high contamination; B, high contamination), and 1,772 age-matched women from the surrounding noncontaminated area (reference); (ii) a biomarker study on 51 mother-child pairs for whom recent maternal plasma dioxin measurements were available. Neonatal blood thyroid-stimulating hormone (b-TSH) was measured on all children. We performed crude and multivariate analyses adjusting for gender, birth weight, birth order, maternal age, hospital, and type of delivery. Mean neonatal b-TSH was 0.98 μU/ml (95% confidence interval [CI] 0.90-1.08) in the reference area (n = 533), 1.35 μU/ml (95% CI 1.22-1.49) in zone B (n = 425), and 1.66 μU/ml (95% CI 1.19-2.31) in zone A (n = 56) (p <0.001). The proportion of children with b-TSH > 5 μU/ml was 2.8% in the reference area, 4.9% in zone B, and 16.1% in zone A (p <0.001). Neonatal b-TSH was correlated with current maternal plasma TCDD (n = 51, β = 0.47, p <0.001) and plasma toxic equivalents of coplanar dioxin-like compounds (n = 51, β = 0.45, p = 0.005). Conclusions: Our data indicate that environmental contaminants such as dioxins have a long-lasting capability to modify neonatal thyroid function after the initial exposure. Copyright:

Original languageEnglish
Pages (from-to)1133-1142
Number of pages10
JournalPLoS Medicine
Volume5
Issue number7
DOIs
Publication statusPublished - Jul 2008

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Maternal Exposure
Dioxins
Thyrotropin
Thyroid Gland
Blood
Poisons
Mothers
Confidence Intervals
Impurities
Plasmas
Contamination
Birth Order
Maternal Age
Biomarkers
Hypothyroidism
Birth Weight
Italy
Population
Accidents
Animals

ASJC Scopus subject areas

  • Medicine(all)

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Neonatal thyroid function in seveso 25 years after maternal exposure to dioxin. / Baccarelli, Andrea; Giacomini, Sara M.; Corbetta, Carlo; Landi, Maria Teresa; Bonzini, Matteo; Consonni, Dario; Grillo, Paolo; Patterson, Donald G.; Pesatori, Angela C.; Bertazzi, Pier Alberto.

In: PLoS Medicine, Vol. 5, No. 7, 07.2008, p. 1133-1142.

Research output: Contribution to journalArticle

Baccarelli, Andrea ; Giacomini, Sara M. ; Corbetta, Carlo ; Landi, Maria Teresa ; Bonzini, Matteo ; Consonni, Dario ; Grillo, Paolo ; Patterson, Donald G. ; Pesatori, Angela C. ; Bertazzi, Pier Alberto. / Neonatal thyroid function in seveso 25 years after maternal exposure to dioxin. In: PLoS Medicine. 2008 ; Vol. 5, No. 7. pp. 1133-1142.
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abstract = "Background: Neonatal hypothyroidism has been associated in animal models with maternal exposure to several environmental contaminants; however, evidence for such an association in humans is inconsistent. We evaluated whether maternal exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a persistent and widespread toxic environmental contaminant, is associated with modified neonatal thyroid function in a large, highly exposed population in Seveso, Italy. Methods and Findings: Between 1994 and 2005, in individuals exposed to TCDD after the 1976 Seveso accident we conducted: (i) a residence-based population study on 1,014 children born to the 1,772 women of reproductive age in the most contaminated zones (A, very high contamination; B, high contamination), and 1,772 age-matched women from the surrounding noncontaminated area (reference); (ii) a biomarker study on 51 mother-child pairs for whom recent maternal plasma dioxin measurements were available. Neonatal blood thyroid-stimulating hormone (b-TSH) was measured on all children. We performed crude and multivariate analyses adjusting for gender, birth weight, birth order, maternal age, hospital, and type of delivery. Mean neonatal b-TSH was 0.98 μU/ml (95{\%} confidence interval [CI] 0.90-1.08) in the reference area (n = 533), 1.35 μU/ml (95{\%} CI 1.22-1.49) in zone B (n = 425), and 1.66 μU/ml (95{\%} CI 1.19-2.31) in zone A (n = 56) (p <0.001). The proportion of children with b-TSH > 5 μU/ml was 2.8{\%} in the reference area, 4.9{\%} in zone B, and 16.1{\%} in zone A (p <0.001). Neonatal b-TSH was correlated with current maternal plasma TCDD (n = 51, β = 0.47, p <0.001) and plasma toxic equivalents of coplanar dioxin-like compounds (n = 51, β = 0.45, p = 0.005). Conclusions: Our data indicate that environmental contaminants such as dioxins have a long-lasting capability to modify neonatal thyroid function after the initial exposure. Copyright:",
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AU - Baccarelli, Andrea

AU - Giacomini, Sara M.

AU - Corbetta, Carlo

AU - Landi, Maria Teresa

AU - Bonzini, Matteo

AU - Consonni, Dario

AU - Grillo, Paolo

AU - Patterson, Donald G.

AU - Pesatori, Angela C.

AU - Bertazzi, Pier Alberto

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N2 - Background: Neonatal hypothyroidism has been associated in animal models with maternal exposure to several environmental contaminants; however, evidence for such an association in humans is inconsistent. We evaluated whether maternal exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a persistent and widespread toxic environmental contaminant, is associated with modified neonatal thyroid function in a large, highly exposed population in Seveso, Italy. Methods and Findings: Between 1994 and 2005, in individuals exposed to TCDD after the 1976 Seveso accident we conducted: (i) a residence-based population study on 1,014 children born to the 1,772 women of reproductive age in the most contaminated zones (A, very high contamination; B, high contamination), and 1,772 age-matched women from the surrounding noncontaminated area (reference); (ii) a biomarker study on 51 mother-child pairs for whom recent maternal plasma dioxin measurements were available. Neonatal blood thyroid-stimulating hormone (b-TSH) was measured on all children. We performed crude and multivariate analyses adjusting for gender, birth weight, birth order, maternal age, hospital, and type of delivery. Mean neonatal b-TSH was 0.98 μU/ml (95% confidence interval [CI] 0.90-1.08) in the reference area (n = 533), 1.35 μU/ml (95% CI 1.22-1.49) in zone B (n = 425), and 1.66 μU/ml (95% CI 1.19-2.31) in zone A (n = 56) (p <0.001). The proportion of children with b-TSH > 5 μU/ml was 2.8% in the reference area, 4.9% in zone B, and 16.1% in zone A (p <0.001). Neonatal b-TSH was correlated with current maternal plasma TCDD (n = 51, β = 0.47, p <0.001) and plasma toxic equivalents of coplanar dioxin-like compounds (n = 51, β = 0.45, p = 0.005). Conclusions: Our data indicate that environmental contaminants such as dioxins have a long-lasting capability to modify neonatal thyroid function after the initial exposure. Copyright:

AB - Background: Neonatal hypothyroidism has been associated in animal models with maternal exposure to several environmental contaminants; however, evidence for such an association in humans is inconsistent. We evaluated whether maternal exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a persistent and widespread toxic environmental contaminant, is associated with modified neonatal thyroid function in a large, highly exposed population in Seveso, Italy. Methods and Findings: Between 1994 and 2005, in individuals exposed to TCDD after the 1976 Seveso accident we conducted: (i) a residence-based population study on 1,014 children born to the 1,772 women of reproductive age in the most contaminated zones (A, very high contamination; B, high contamination), and 1,772 age-matched women from the surrounding noncontaminated area (reference); (ii) a biomarker study on 51 mother-child pairs for whom recent maternal plasma dioxin measurements were available. Neonatal blood thyroid-stimulating hormone (b-TSH) was measured on all children. We performed crude and multivariate analyses adjusting for gender, birth weight, birth order, maternal age, hospital, and type of delivery. Mean neonatal b-TSH was 0.98 μU/ml (95% confidence interval [CI] 0.90-1.08) in the reference area (n = 533), 1.35 μU/ml (95% CI 1.22-1.49) in zone B (n = 425), and 1.66 μU/ml (95% CI 1.19-2.31) in zone A (n = 56) (p <0.001). The proportion of children with b-TSH > 5 μU/ml was 2.8% in the reference area, 4.9% in zone B, and 16.1% in zone A (p <0.001). Neonatal b-TSH was correlated with current maternal plasma TCDD (n = 51, β = 0.47, p <0.001) and plasma toxic equivalents of coplanar dioxin-like compounds (n = 51, β = 0.45, p = 0.005). Conclusions: Our data indicate that environmental contaminants such as dioxins have a long-lasting capability to modify neonatal thyroid function after the initial exposure. Copyright:

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