Abstract
Aims - To define the aetiology of neonatal transient hypothyroidism (NTH) and recommend preventive measures. Methods - Maternal and perinatal clinical data on the use of antiseptics, drugs, and contrast agents containing iodine were collected from 40 subjects. Thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroxine (T4), thyroglobulin (TG), TSH receptor antibodies, thyroid peroxidase antibodies and urinary iodine were measured in random neonatal samples. In the mothers with known or suspected thyroid disorders, TSH, FT4, TSH receptor antibodies and thyroid peroxidase antibodies were also measured. Results - The NTH aetiology was identified in 85% of cases. More than 50% of the babies with transient hypothyroidism had been exposed to iodine; maternal transfer of antibodies had occurred in a third of them. Conclusions - It is suggested that the practice of using iodine containing disinfectants should be withdrawn, and chlorhexidine substituted instead; that pregnant women should be advised of the adverse effects of using iodine products; and that thyroid function should be monitored whenever iodine is used.
| Original language | English |
|---|---|
| Journal | Archives of Disease in Childhood: Fetal and Neonatal Edition |
| Volume | 79 |
| Issue number | 1 |
| Publication status | Published - 1998 |
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Keywords
- Iodine
- Screening
- Thyroid antibody
- Transient hypothyroidism
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Neonatal transient hypothyroidism : Aetiological study. / Weber, G.; Vigone, M. C.; Rapa, A.; Bona, G.; Chiumello, G.; Torresani, P.; Longhi, R.; Bini, P.; Maccabruni, M.; Frisone, F.; Cacciari, E.; Cassio, A.; Severi, F.; Larizza, D.; De Sanctis, C.; Corrias, A.; Zannini, R.; Masperi, R.; Moschini, I.; Costa, P.
In: Archives of Disease in Childhood: Fetal and Neonatal Edition, Vol. 79, No. 1, 1998.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neonatal transient hypothyroidism
T2 - Aetiological study
AU - Weber, G.
AU - Vigone, M. C.
AU - Rapa, A.
AU - Bona, G.
AU - Chiumello, G.
AU - Torresani, P.
AU - Longhi, R.
AU - Bini, P.
AU - Maccabruni, M.
AU - Frisone, F.
AU - Cacciari, E.
AU - Cassio, A.
AU - Severi, F.
AU - Larizza, D.
AU - De Sanctis, C.
AU - Corrias, A.
AU - Zannini, R.
AU - Masperi, R.
AU - Moschini, I.
AU - Costa, P.
PY - 1998
Y1 - 1998
N2 - Aims - To define the aetiology of neonatal transient hypothyroidism (NTH) and recommend preventive measures. Methods - Maternal and perinatal clinical data on the use of antiseptics, drugs, and contrast agents containing iodine were collected from 40 subjects. Thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroxine (T4), thyroglobulin (TG), TSH receptor antibodies, thyroid peroxidase antibodies and urinary iodine were measured in random neonatal samples. In the mothers with known or suspected thyroid disorders, TSH, FT4, TSH receptor antibodies and thyroid peroxidase antibodies were also measured. Results - The NTH aetiology was identified in 85% of cases. More than 50% of the babies with transient hypothyroidism had been exposed to iodine; maternal transfer of antibodies had occurred in a third of them. Conclusions - It is suggested that the practice of using iodine containing disinfectants should be withdrawn, and chlorhexidine substituted instead; that pregnant women should be advised of the adverse effects of using iodine products; and that thyroid function should be monitored whenever iodine is used.
AB - Aims - To define the aetiology of neonatal transient hypothyroidism (NTH) and recommend preventive measures. Methods - Maternal and perinatal clinical data on the use of antiseptics, drugs, and contrast agents containing iodine were collected from 40 subjects. Thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroxine (T4), thyroglobulin (TG), TSH receptor antibodies, thyroid peroxidase antibodies and urinary iodine were measured in random neonatal samples. In the mothers with known or suspected thyroid disorders, TSH, FT4, TSH receptor antibodies and thyroid peroxidase antibodies were also measured. Results - The NTH aetiology was identified in 85% of cases. More than 50% of the babies with transient hypothyroidism had been exposed to iodine; maternal transfer of antibodies had occurred in a third of them. Conclusions - It is suggested that the practice of using iodine containing disinfectants should be withdrawn, and chlorhexidine substituted instead; that pregnant women should be advised of the adverse effects of using iodine products; and that thyroid function should be monitored whenever iodine is used.
KW - Iodine
KW - Screening
KW - Thyroid antibody
KW - Transient hypothyroidism
UR - http://www.scopus.com/inward/record.url?scp=0005094049&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0005094049&partnerID=8YFLogxK
M3 - Article
VL - 79
JO - Archives of Disease in Childhood: Fetal and Neonatal Edition
JF - Archives of Disease in Childhood: Fetal and Neonatal Edition
SN - 1359-2998
IS - 1
ER -