Neonatal transient hypothyroidism

Aetiological study

G. Weber, M. C. Vigone, A. Rapa, G. Bona, G. Chiumello, P. Torresani, R. Longhi, P. Bini, M. Maccabruni, F. Frisone, E. Cacciari, A. Cassio, F. Severi, D. Larizza, C. De Sanctis, A. Corrias, R. Zannini, R. Masperi, I. Moschini, P. Costa

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Aims - To define the aetiology of neonatal transient hypothyroidism (NTH) and recommend preventive measures. Methods - Maternal and perinatal clinical data on the use of antiseptics, drugs, and contrast agents containing iodine were collected from 40 subjects. Thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroxine (T4), thyroglobulin (TG), TSH receptor antibodies, thyroid peroxidase antibodies and urinary iodine were measured in random neonatal samples. In the mothers with known or suspected thyroid disorders, TSH, FT4, TSH receptor antibodies and thyroid peroxidase antibodies were also measured. Results - The NTH aetiology was identified in 85% of cases. More than 50% of the babies with transient hypothyroidism had been exposed to iodine; maternal transfer of antibodies had occurred in a third of them. Conclusions - It is suggested that the practice of using iodine containing disinfectants should be withdrawn, and chlorhexidine substituted instead; that pregnant women should be advised of the adverse effects of using iodine products; and that thyroid function should be monitored whenever iodine is used.

Original languageEnglish
JournalArchives of Disease in Childhood: Fetal and Neonatal Edition
Volume79
Issue number1
Publication statusPublished - 1998

Fingerprint

Hypothyroidism
Iodine
Antibodies
Thyrotropin Receptors
Iodide Peroxidase
Mothers
Thyrotropin
Thyroxine
Thyroid Gland
Local Anti-Infective Agents
Chlorhexidine
Thyroglobulin
Disinfectants
Contrast Media
Pregnant Women
Pharmaceutical Preparations

Keywords

  • Iodine
  • Screening
  • Thyroid antibody
  • Transient hypothyroidism

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Weber, G., Vigone, M. C., Rapa, A., Bona, G., Chiumello, G., Torresani, P., ... Costa, P. (1998). Neonatal transient hypothyroidism: Aetiological study. Archives of Disease in Childhood: Fetal and Neonatal Edition, 79(1).

Neonatal transient hypothyroidism : Aetiological study. / Weber, G.; Vigone, M. C.; Rapa, A.; Bona, G.; Chiumello, G.; Torresani, P.; Longhi, R.; Bini, P.; Maccabruni, M.; Frisone, F.; Cacciari, E.; Cassio, A.; Severi, F.; Larizza, D.; De Sanctis, C.; Corrias, A.; Zannini, R.; Masperi, R.; Moschini, I.; Costa, P.

In: Archives of Disease in Childhood: Fetal and Neonatal Edition, Vol. 79, No. 1, 1998.

Research output: Contribution to journalArticle

Weber, G, Vigone, MC, Rapa, A, Bona, G, Chiumello, G, Torresani, P, Longhi, R, Bini, P, Maccabruni, M, Frisone, F, Cacciari, E, Cassio, A, Severi, F, Larizza, D, De Sanctis, C, Corrias, A, Zannini, R, Masperi, R, Moschini, I & Costa, P 1998, 'Neonatal transient hypothyroidism: Aetiological study', Archives of Disease in Childhood: Fetal and Neonatal Edition, vol. 79, no. 1.
Weber, G. ; Vigone, M. C. ; Rapa, A. ; Bona, G. ; Chiumello, G. ; Torresani, P. ; Longhi, R. ; Bini, P. ; Maccabruni, M. ; Frisone, F. ; Cacciari, E. ; Cassio, A. ; Severi, F. ; Larizza, D. ; De Sanctis, C. ; Corrias, A. ; Zannini, R. ; Masperi, R. ; Moschini, I. ; Costa, P. / Neonatal transient hypothyroidism : Aetiological study. In: Archives of Disease in Childhood: Fetal and Neonatal Edition. 1998 ; Vol. 79, No. 1.
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AU - Torresani, P.

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AU - Costa, P.

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