TY - JOUR
T1 - Neonatal vesiculopustular eruption in Down syndrome and transient myeloproliferative disorder
T2 - A case report and review of the literature
AU - Brazzelli, Valeria
AU - Segal, Aviad
AU - Bernacca, Carlotta
AU - Tchich, Adi
AU - Bolcato, Vittorio
AU - Croci, Giorgio
AU - Mina, Tommaso
AU - Zecca, Marco
AU - Zanette, Simona
AU - Stronati, Mauro
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Transient myeloproliferative disorder (TMD) is a spontaneously resolving clonal myeloid proliferation characterized by circulating megakaryoblasts in the peripheral blood that is restricted to neonates with Down syndrome (DS) or those with trisomy 21 mosaicism. Cutaneous manifestations of TMD are observed in only 5% of affected neonates and present as a diffuse eruption of erythematous, crusted papules, papulovesicles, and pustules, often with prominent and initial facial involvement. We describe the case of a male infant with DS and TMD, associated with a vesiculopustular eruption, which appeared on day 36 of life, and review previous cases.
AB - Transient myeloproliferative disorder (TMD) is a spontaneously resolving clonal myeloid proliferation characterized by circulating megakaryoblasts in the peripheral blood that is restricted to neonates with Down syndrome (DS) or those with trisomy 21 mosaicism. Cutaneous manifestations of TMD are observed in only 5% of affected neonates and present as a diffuse eruption of erythematous, crusted papules, papulovesicles, and pustules, often with prominent and initial facial involvement. We describe the case of a male infant with DS and TMD, associated with a vesiculopustular eruption, which appeared on day 36 of life, and review previous cases.
KW - Down syndrome
KW - neonatal vesiculopustular eruption
KW - transient myeloproliferative disorder
KW - trisomy 21
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U2 - 10.1111/pde.13931
DO - 10.1111/pde.13931
M3 - Article
C2 - 31355466
AN - SCOPUS:85072366601
VL - 36
SP - 702
EP - 706
JO - Pediatric Dermatology
JF - Pediatric Dermatology
SN - 0736-8046
IS - 5
ER -