Neonatal vesiculopustular eruption in Down syndrome and transient myeloproliferative disorder: A case report and review of the literature

Valeria Brazzelli, Aviad Segal, Carlotta Bernacca, Adi Tchich, Vittorio Bolcato, Giorgio Croci, Tommaso Mina, Marco Zecca, Simona Zanette, Mauro Stronati

Research output: Contribution to journalArticlepeer-review

Abstract

Transient myeloproliferative disorder (TMD) is a spontaneously resolving clonal myeloid proliferation characterized by circulating megakaryoblasts in the peripheral blood that is restricted to neonates with Down syndrome (DS) or those with trisomy 21 mosaicism. Cutaneous manifestations of TMD are observed in only 5% of affected neonates and present as a diffuse eruption of erythematous, crusted papules, papulovesicles, and pustules, often with prominent and initial facial involvement. We describe the case of a male infant with DS and TMD, associated with a vesiculopustular eruption, which appeared on day 36 of life, and review previous cases.

Original languageEnglish
Pages (from-to)702-706
Number of pages5
JournalPediatric Dermatology
Volume36
Issue number5
DOIs
Publication statusPublished - Sep 1 2019

Keywords

  • Down syndrome
  • neonatal vesiculopustular eruption
  • transient myeloproliferative disorder
  • trisomy 21

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Dermatology

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