Abstract
Tumors of the adrenal glands cause a variety of endocrine disturbances including not only Cushing's and the adrenogenital syndromes but also hypertension. The ready availability of novel imaging techniques has resulted in an increased recognition of hitherto unsuspected adrenal lesions. Most are small and without overt function but a significant number of pheochromocytomas are found in this manner. Several familial syndromes have been found to be the basis for the development of pheochromocytomas and paragangliomas. The etiology of adrenocortical tumors remains unknown, although the molecular changes associated with progression and malignancy have become better appreciated. The distinction of benign from malignant tumors relies principally on histology and remains difficult in many instances. Surgery is the only method of cure; chemotherapy is unhelpful such that the outlook for patients with advanced carcinomas is poor.
| Original language | English |
|---|---|
| Title of host publication | Textbook of Uncommon Cancer, Third Edition |
| Publisher | John Wiley & Sons, Ltd |
| Pages | 143-164 |
| Number of pages | 22 |
| ISBN (Print) | 0470012021, 9780470012024 |
| DOIs | |
| Publication status | Published - Jul 11 2006 |
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Keywords
- Adrenal tumors
- Adrenocortical tumors-Cushing's syndrome
- Adrenogenital syndrome
- Conn's syndrome
- Incidentaloma
- Management-surgery-chemotherapy
- Paraganglioma
- Pheochromocytoma
ASJC Scopus subject areas
- Medicine(all)
Cite this
Neoplastic Disorders of the Adrenal Glands. / Oberg, K.; Goldhirsch, A.; Neville, A. Munro.
Textbook of Uncommon Cancer, Third Edition. John Wiley & Sons, Ltd, 2006. p. 143-164.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Neoplastic Disorders of the Adrenal Glands
AU - Oberg, K.
AU - Goldhirsch, A.
AU - Neville, A. Munro
PY - 2006/7/11
Y1 - 2006/7/11
N2 - Tumors of the adrenal glands cause a variety of endocrine disturbances including not only Cushing's and the adrenogenital syndromes but also hypertension. The ready availability of novel imaging techniques has resulted in an increased recognition of hitherto unsuspected adrenal lesions. Most are small and without overt function but a significant number of pheochromocytomas are found in this manner. Several familial syndromes have been found to be the basis for the development of pheochromocytomas and paragangliomas. The etiology of adrenocortical tumors remains unknown, although the molecular changes associated with progression and malignancy have become better appreciated. The distinction of benign from malignant tumors relies principally on histology and remains difficult in many instances. Surgery is the only method of cure; chemotherapy is unhelpful such that the outlook for patients with advanced carcinomas is poor.
AB - Tumors of the adrenal glands cause a variety of endocrine disturbances including not only Cushing's and the adrenogenital syndromes but also hypertension. The ready availability of novel imaging techniques has resulted in an increased recognition of hitherto unsuspected adrenal lesions. Most are small and without overt function but a significant number of pheochromocytomas are found in this manner. Several familial syndromes have been found to be the basis for the development of pheochromocytomas and paragangliomas. The etiology of adrenocortical tumors remains unknown, although the molecular changes associated with progression and malignancy have become better appreciated. The distinction of benign from malignant tumors relies principally on histology and remains difficult in many instances. Surgery is the only method of cure; chemotherapy is unhelpful such that the outlook for patients with advanced carcinomas is poor.
KW - Adrenal tumors
KW - Adrenocortical tumors-Cushing's syndrome
KW - Adrenogenital syndrome
KW - Conn's syndrome
KW - Incidentaloma
KW - Management-surgery-chemotherapy
KW - Paraganglioma
KW - Pheochromocytoma
UR - http://www.scopus.com/inward/record.url?scp=84889379001&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84889379001&partnerID=8YFLogxK
U2 - 10.1002/0470030542.ch10
DO - 10.1002/0470030542.ch10
M3 - Chapter
AN - SCOPUS:84889379001
SN - 0470012021
SN - 9780470012024
SP - 143
EP - 164
BT - Textbook of Uncommon Cancer, Third Edition
PB - John Wiley & Sons, Ltd
ER -