Neoplastic involvement of nipple-areolar complex in invasive breast cancer

Donatella Santini, Mario Taffurelli, Maria Carolina Gelli, Alberto Grassigli, Francesco Giosa, Domenico Marrano, Giuseppe Martinelli

Research output: Contribution to journalArticle

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Abstract

The neoplastic involvement of the nipple-areolar complex was histologically studied in 1,291 available consecutive mastectomy specimens with primary invasive breast carcinoma. Tumor involvement of the nipple-areolar complex was found in 150 specimens (12 percent) and was not suspected on gross examination in 99 patients (8 percent). A significant finding of our study was the relatively high rate of tumor foci in the nipple-areolar complex (7 percent) in those patients with early invasive stage I or II breast carcinoma eligible for conservative therapy. Analysis of nipple-areolar complex involvement with consideration of different clinicomorphologic variables indicates that it was directly associated with tumor size. No significant correlation was found with axillary metastases, tumor histologic type, or with the presence of noninvasive cancer in the vicinity of the dominant tumor. Our estimate of the significant chance of finding tumor in the nipple-areolar complex, especially in the patient group eligible for conservative therapy, underlines the need for postoperative radiation.

Original languageEnglish
Pages (from-to)399-403
Number of pages5
JournalAmerican Journal of Surgery
Volume158
Issue number5
DOIs
Publication statusPublished - 1989

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Nipples
Breast Neoplasms
Neoplasms
Mastectomy
Radiation
Neoplasm Metastasis

ASJC Scopus subject areas

  • Surgery

Cite this

Santini, D., Taffurelli, M., Gelli, M. C., Grassigli, A., Giosa, F., Marrano, D., & Martinelli, G. (1989). Neoplastic involvement of nipple-areolar complex in invasive breast cancer. American Journal of Surgery, 158(5), 399-403. https://doi.org/10.1016/0002-9610(89)90272-9

Neoplastic involvement of nipple-areolar complex in invasive breast cancer. / Santini, Donatella; Taffurelli, Mario; Gelli, Maria Carolina; Grassigli, Alberto; Giosa, Francesco; Marrano, Domenico; Martinelli, Giuseppe.

In: American Journal of Surgery, Vol. 158, No. 5, 1989, p. 399-403.

Research output: Contribution to journalArticle

Santini, D, Taffurelli, M, Gelli, MC, Grassigli, A, Giosa, F, Marrano, D & Martinelli, G 1989, 'Neoplastic involvement of nipple-areolar complex in invasive breast cancer', American Journal of Surgery, vol. 158, no. 5, pp. 399-403. https://doi.org/10.1016/0002-9610(89)90272-9
Santini D, Taffurelli M, Gelli MC, Grassigli A, Giosa F, Marrano D et al. Neoplastic involvement of nipple-areolar complex in invasive breast cancer. American Journal of Surgery. 1989;158(5):399-403. https://doi.org/10.1016/0002-9610(89)90272-9
Santini, Donatella ; Taffurelli, Mario ; Gelli, Maria Carolina ; Grassigli, Alberto ; Giosa, Francesco ; Marrano, Domenico ; Martinelli, Giuseppe. / Neoplastic involvement of nipple-areolar complex in invasive breast cancer. In: American Journal of Surgery. 1989 ; Vol. 158, No. 5. pp. 399-403.
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