Neoplastic meningitis from breast carcinoma with complete response to liposomal cytarabine: Case report

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Abstract

Neoplastic meningitis from breast cancer often leads to a progressive neurologic deterioration followed by fatal outcome. The therapy is based on the administration of high dose systemic chemotherapy with drugs able to pass through the blood-brain barrier, such as methotrexate (MTX) and cytarabine, cranial or craniospinal irradiation, and intrathecal (IT) administration of MTX and/or cytarabine. However, these approaches only have modest efficacy and are associated with side effects for the patients. A depot formulation of liposomal cytarabine (DepoCyte®) has proven to be useful in clinical trials. We describe the case of a woman with a diagnosis of leptomeningeal carcinomatosis from breast carcinoma who presented cerebrospinal fluid normalization and prolonged complete MRI response to intrathecal chemotherapy with liposomal cytarabine (DepoCyte).

Original languageEnglish
Pages (from-to)251-254
Number of pages4
JournalNeurological Sciences
Volume30
Issue number3
DOIs
Publication statusPublished - 2009

Keywords

  • Breast carcinoma
  • Chemotherapy
  • Liposomal cytarabine
  • Neoplastic meningitis

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

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