TY - JOUR
T1 - Neoplastic meningitis from breast carcinoma with complete response to liposomal cytarabine
T2 - Case report
AU - Gaviani, Paola
AU - Silvani, A.
AU - Corsini, E.
AU - Erbetta, A.
AU - Salmaggi, A.
PY - 2009
Y1 - 2009
N2 - Neoplastic meningitis from breast cancer often leads to a progressive neurologic deterioration followed by fatal outcome. The therapy is based on the administration of high dose systemic chemotherapy with drugs able to pass through the blood-brain barrier, such as methotrexate (MTX) and cytarabine, cranial or craniospinal irradiation, and intrathecal (IT) administration of MTX and/or cytarabine. However, these approaches only have modest efficacy and are associated with side effects for the patients. A depot formulation of liposomal cytarabine (DepoCyte®) has proven to be useful in clinical trials. We describe the case of a woman with a diagnosis of leptomeningeal carcinomatosis from breast carcinoma who presented cerebrospinal fluid normalization and prolonged complete MRI response to intrathecal chemotherapy with liposomal cytarabine (DepoCyte).
AB - Neoplastic meningitis from breast cancer often leads to a progressive neurologic deterioration followed by fatal outcome. The therapy is based on the administration of high dose systemic chemotherapy with drugs able to pass through the blood-brain barrier, such as methotrexate (MTX) and cytarabine, cranial or craniospinal irradiation, and intrathecal (IT) administration of MTX and/or cytarabine. However, these approaches only have modest efficacy and are associated with side effects for the patients. A depot formulation of liposomal cytarabine (DepoCyte®) has proven to be useful in clinical trials. We describe the case of a woman with a diagnosis of leptomeningeal carcinomatosis from breast carcinoma who presented cerebrospinal fluid normalization and prolonged complete MRI response to intrathecal chemotherapy with liposomal cytarabine (DepoCyte).
KW - Breast carcinoma
KW - Chemotherapy
KW - Liposomal cytarabine
KW - Neoplastic meningitis
UR - http://www.scopus.com/inward/record.url?scp=67349230634&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349230634&partnerID=8YFLogxK
U2 - 10.1007/s10072-009-0044-8
DO - 10.1007/s10072-009-0044-8
M3 - Article
C2 - 19259616
AN - SCOPUS:67349230634
VL - 30
SP - 251
EP - 254
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 3
ER -