Neoplastic pericardial disease in lung cancer: Impact on outcomes of different treatment strategies. A multicenter study

Chiara Lestuzzi, Alessandra Bearz, Christos Lafaras, Renata Gralec, Eugenio Cervesato, Witold Tomkowski, Marzia DeBiasio, Elda Viel, Theodoros Bishiniotis, Dimitrios N. Platogiannis, Angela Buonadonna, Lucia Tartuferi, Rita Piazza, Salvatore Tumolo, Massimiliano Berretta, Francesco Santini, Massimo Imazio

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Local (intrapericardial) chemotherapy has been reported to be useful for the treatment of neoplastic pericardial disease, but it has never been compared to systemic chemotherapy, a combination of the two and simple pericardial drainage or sclerosis. Methods: We analyzed the clinical and echocardiographic data of 119 patients, suffering of neoplastic pericarditis due to lung cancer (97 with non-small-cell), comparing the outcomes of four different treatment strategies (extended catheter drainage/sclerosis, systemic chemotherapy, local chemotherapy, and combined - local plus systemic - chemotherapy) at the last available follow-up or at the change of therapy after a treatment failure. The outcomes (based on semiquantitative evaluation of pericardial disease) were classified as complete, partial, no response and progressing disease. Results: A complete response was achieved in 37/53 of patients with combined, in 12/22 with local, in 5/27 with systemic chemotherapy, respectively, and in 4/17 after drainage/sclerosis (p2=7.69, p

Original languageEnglish
Pages (from-to)340-347
Number of pages8
JournalLung Cancer
Volume72
Issue number3
DOIs
Publication statusPublished - Jun 2011

Keywords

  • Chemotherapy
  • Intrapericardial instillation
  • Lung cancer
  • Malignant pericardial effusion

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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