Nephrectomy improves the survival of patients with locally advanced renal cell carcinoma

Laurent Zini, Paul Perrotte, Claudio Jeldres, Umberto Capitanio, Daniel Pharand, Philippe Arjane, Steven Lapointe, Francesco Montorsi, Jean Jacques Patard, Pierre I. Karakiewicz

Research output: Contribution to journalArticlepeer-review


OBJECTIVES: To examine the cancer-specific survival of patients treated with nephrectomy and compared it to that of patients managed without surgery. PATIENTS AND METHODS: Of 43 143 patients with renal cell carcinoma (RCC) identified in the 1988-2004 Surveillance, Epidemiology and End Results database, 7068 had locally advanced RCC and with no distant metastasis. These patients had a nephrectomy (6786, 96.0%) or no surgical therapy (282, 4.0%). Multivariable Cox regression models, and matched and unmatched Kaplan-Meier survival analyses, were used to compare the effect of nephrectomy vs non-surgical therapy on cancer-specific survival. Also, competing-risks regression models adjusted for the effect of other-cause mortality. Covariates and matching variables consisted of age, gender, tumour size and year of diagnosis. RESULTS: The 1-, 2-, 5- and 10-year cancer-specific survival of patients who had nephrectomy was 88.9%, 88.1%, 68.6% and 57.5%, vs 44.8%, 30.6%, 14.5% and 10.6% for non-surgical therapy. In multivariable analyses, relative to nephrectomy, non-surgical therapy was associated with a 5.8-fold higher rate of cancer-specific mortality (P <0.001). Non-surgical therapy was also associated with a 5.1-fold higher rate of cancer-specific mortality in matched analyses (P <0.001). Finally, competing-risks regression confirmed the statistical significance of the variable defining treatment type (nephrectomy vs non-surgical therapy) in multivariable and matched analyses (P <0.001). CONCLUSION: Relative to non-surgical treatment, nephrectomy improves the cancer-specific survival of patients with locally advanced RCC; our findings await prospective confirmation.

Original languageEnglish
Pages (from-to)1610-1614
Number of pages5
JournalBJU International
Issue number11
Publication statusPublished - Dec 2008


  • Cancer-specific survival
  • Conservative management
  • Kidney neoplasm
  • Locally advanced stage
  • Natural history
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Urology


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