Nerds syndrome: An additional case report

P. Zenarola, L. Melillo, M. Bisceglia, M. Carotenuto, M. Lomuto

Research output: Contribution to journalArticlepeer-review


NERDS is an eosinophilic disorder recently described by Butterfield and characterized by an association of nodules, eosinophilia. rheumatism, dermatitis and swelling. We describe an additional case, the third, of this new eosinophilic syndrome. The cardinal features included joint and cutaneous manifestations with prominent para-articular nodules and rheumatism, xerosis, recurrent urticarial eruption with angioedema associated with tissue and peripheral blood eosinophilia. A drug-induced (diclofenac) allergic rash and lymphadenopathy appeared during the course of the illness. Persistent leukocytosis with a maximum of 65% of eosinophils, mostly exhibiting the hypodense phenotype (activation index), was always present. During the acute phase of the disease, flow-cytometric analysis of blood and bone marrow revealed proliferation of activated CD4+/OKDR+ T helper cells and CD25+/OKDR+ eosinophils.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
Issue number2
Publication statusPublished - 1995


  • Eosinophilia
  • Nerds syndrome diclofenac
  • Nodules
  • Para-articular
  • Rheumatism
  • Urticaria
  • Xerosis

ASJC Scopus subject areas

  • Dermatology


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