Nerve growth factor: A focus on neuroscience and therapy

Luigi Aloe, Maria Luisa Rocco, Bijorn Omar Balzamino, Alessandra Micera

Research output: Contribution to journalArticlepeer-review


Nerve growth factor (NGF) is the firstly discovered and best characterized neurotrophic factor, known to play a critical protective role in the development and survival of sympathetic, sensory and forebrain cholinergic neurons. NGF promotes neuritis outgrowth both in vivo and in vitro and nerve cell recovery after ischemic, surgical or chemical injuries. Recently, the therapeutic property of NGF has been demonstrated on human cutaneous and corneal ulcers, pressure ulcer, glaucoma, maculopathy and retinitis pigmentosa. NGF eye drops administration is well tolerated, with no detectable clinical evidence of systemic or local adverse effects. The aim of this review is to summarize these biological properties and the potential clinical development of NGF.

Original languageEnglish
Pages (from-to)294-303
Number of pages10
JournalCurrent Neuropharmacology
Issue number3
Publication statusPublished - Jul 1 2015


  • Clinical trials
  • NGF
  • NGF receptors
  • NGF-healing action
  • Treatment
  • Visual system

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Pharmacology
  • Neurology
  • Psychiatry and Mental health

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