Nerve growth factor and neuropeptides circulating levels in systemic sclerosis (scleroderma)

M. Matucci-Cerinic; R. Giacomelli; A. Pignone; M. Cagnoni; S. Generini; R. Casale; P. Cipriani; A. Del Rosso; P. Tirassa; Y. T. Konttinen; B. M. Kahaleh; P. S. Fan; M. Paoletti; C. Marchesi; L. Aloe; M. L. Cagnoni

doi:10.1136/ard.60.5.487

Nerve growth factor and neuropeptides circulating levels in systemic sclerosis (scleroderma)

M. Matucci-Cerinic, R. Giacomelli, A. Pignone, M. Cagnoni, S. Generini, R. Casale, P. Cipriani, A. Del Rosso, P. Tirassa, Y. T. Konttinen, B. M. Kahaleh, P. S. Fan, M. Paoletti, C. Marchesi, L. Aloe, M. L. Cagnoni

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

Objective - To determine the circulating levels of nerve growth factor (NGF), neuropeptide Y (NPY), and vasoactive intestinal peptide (VIP) in systemic sclerosis (SSc), and to correlate these levels with clinical and laboratory features. Methods - Forty four patients with SSc were evaluated for circulating NGF (immunoenzymatic assay), NPY and VIP (radioimmunoassay), anticentromere and antitopoisomerase I autoantibodies, lung disease (pulmonary function tests with carbon monoxide transfer factor (TLCO), ventilation scintiscan with ^99mTc DTPA radioaerosol, high resolution computed tomography (HRCT), pulmonary pressure (echo colour Doppler)), heart disease (standard and 24 ECG, echocardiography), cutaneous involvement (skin score), joint involvement (evidence of tender or swollen joints, or both), peripheral nervous system (PNS) involvement (electromyography), rheumatoid factor, angiotensin converting enzyme (fluorimetric method), von Willebrand factor (ELISA), and erythrocyte sedimentation rate (ESR) (Westergren). Results - Circulating NGF levels in SSc were significantly increased compared with controls (p

Original language	English
Pages (from-to)	487-494
Number of pages	8
Journal	Annals of the Rheumatic Diseases
Volume	60
Issue number	5
DOIs	https://doi.org/10.1136/ard.60.5.487
Publication status	Published - 2001

ASJC Scopus subject areas

Rheumatology
Immunology

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Matucci-Cerinic, M., Giacomelli, R., Pignone, A., Cagnoni, M., Generini, S., Casale, R., Cipriani, P., Del Rosso, A., Tirassa, P., Konttinen, Y. T., Kahaleh, B. M., Fan, P. S., Paoletti, M., Marchesi, C., Aloe, L., & Cagnoni, M. L. (2001). Nerve growth factor and neuropeptides circulating levels in systemic sclerosis (scleroderma). Annals of the Rheumatic Diseases, 60(5), 487-494. https://doi.org/10.1136/ard.60.5.487

Nerve growth factor and neuropeptides circulating levels in systemic sclerosis (scleroderma). / Matucci-Cerinic, M.; Giacomelli, R.; Pignone, A.; Cagnoni, M.; Generini, S.; Casale, R.; Cipriani, P.; Del Rosso, A.; Tirassa, P.; Konttinen, Y. T.; Kahaleh, B. M.; Fan, P. S.; Paoletti, M.; Marchesi, C.; Aloe, L.; Cagnoni, M. L.

In: Annals of the Rheumatic Diseases, Vol. 60, No. 5, 2001, p. 487-494.

Research output: Contribution to journal › Article › peer-review

Matucci-Cerinic, M, Giacomelli, R, Pignone, A, Cagnoni, M, Generini, S, Casale, R, Cipriani, P, Del Rosso, A, Tirassa, P, Konttinen, YT, Kahaleh, BM, Fan, PS, Paoletti, M, Marchesi, C, Aloe, L & Cagnoni, ML 2001, 'Nerve growth factor and neuropeptides circulating levels in systemic sclerosis (scleroderma)', Annals of the Rheumatic Diseases, vol. 60, no. 5, pp. 487-494. https://doi.org/10.1136/ard.60.5.487

Matucci-Cerinic, M. ; Giacomelli, R. ; Pignone, A. ; Cagnoni, M. ; Generini, S. ; Casale, R. ; Cipriani, P. ; Del Rosso, A. ; Tirassa, P. ; Konttinen, Y. T. ; Kahaleh, B. M. ; Fan, P. S. ; Paoletti, M. ; Marchesi, C. ; Aloe, L. ; Cagnoni, M. L. / Nerve growth factor and neuropeptides circulating levels in systemic sclerosis (scleroderma). In: Annals of the Rheumatic Diseases. 2001 ; Vol. 60, No. 5. pp. 487-494.

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abstract = "Objective - To determine the circulating levels of nerve growth factor (NGF), neuropeptide Y (NPY), and vasoactive intestinal peptide (VIP) in systemic sclerosis (SSc), and to correlate these levels with clinical and laboratory features. Methods - Forty four patients with SSc were evaluated for circulating NGF (immunoenzymatic assay), NPY and VIP (radioimmunoassay), anticentromere and antitopoisomerase I autoantibodies, lung disease (pulmonary function tests with carbon monoxide transfer factor (TLCO), ventilation scintiscan with 99mTc DTPA radioaerosol, high resolution computed tomography (HRCT), pulmonary pressure (echo colour Doppler)), heart disease (standard and 24 ECG, echocardiography), cutaneous involvement (skin score), joint involvement (evidence of tender or swollen joints, or both), peripheral nervous system (PNS) involvement (electromyography), rheumatoid factor, angiotensin converting enzyme (fluorimetric method), von Willebrand factor (ELISA), and erythrocyte sedimentation rate (ESR) (Westergren). Results - Circulating NGF levels in SSc were significantly increased compared with controls (p",

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AU - Cagnoni, M.

AU - Generini, S.

AU - Casale, R.

AU - Cipriani, P.

AU - Del Rosso, A.

AU - Tirassa, P.

AU - Konttinen, Y. T.

AU - Kahaleh, B. M.

AU - Fan, P. S.

AU - Paoletti, M.

AU - Marchesi, C.

AU - Aloe, L.

AU - Cagnoni, M. L.

PY - 2001

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N2 - Objective - To determine the circulating levels of nerve growth factor (NGF), neuropeptide Y (NPY), and vasoactive intestinal peptide (VIP) in systemic sclerosis (SSc), and to correlate these levels with clinical and laboratory features. Methods - Forty four patients with SSc were evaluated for circulating NGF (immunoenzymatic assay), NPY and VIP (radioimmunoassay), anticentromere and antitopoisomerase I autoantibodies, lung disease (pulmonary function tests with carbon monoxide transfer factor (TLCO), ventilation scintiscan with 99mTc DTPA radioaerosol, high resolution computed tomography (HRCT), pulmonary pressure (echo colour Doppler)), heart disease (standard and 24 ECG, echocardiography), cutaneous involvement (skin score), joint involvement (evidence of tender or swollen joints, or both), peripheral nervous system (PNS) involvement (electromyography), rheumatoid factor, angiotensin converting enzyme (fluorimetric method), von Willebrand factor (ELISA), and erythrocyte sedimentation rate (ESR) (Westergren). Results - Circulating NGF levels in SSc were significantly increased compared with controls (p

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