TY - JOUR
T1 - Nerve growth factor and neuropeptides circulating levels in systemic sclerosis (scleroderma)
AU - Matucci-Cerinic, M.
AU - Giacomelli, R.
AU - Pignone, A.
AU - Cagnoni, M.
AU - Generini, S.
AU - Casale, R.
AU - Cipriani, P.
AU - Del Rosso, A.
AU - Tirassa, P.
AU - Konttinen, Y. T.
AU - Kahaleh, B. M.
AU - Fan, P. S.
AU - Paoletti, M.
AU - Marchesi, C.
AU - Aloe, L.
AU - Cagnoni, M. L.
PY - 2001
Y1 - 2001
N2 - Objective - To determine the circulating levels of nerve growth factor (NGF), neuropeptide Y (NPY), and vasoactive intestinal peptide (VIP) in systemic sclerosis (SSc), and to correlate these levels with clinical and laboratory features. Methods - Forty four patients with SSc were evaluated for circulating NGF (immunoenzymatic assay), NPY and VIP (radioimmunoassay), anticentromere and antitopoisomerase I autoantibodies, lung disease (pulmonary function tests with carbon monoxide transfer factor (TLCO), ventilation scintiscan with 99mTc DTPA radioaerosol, high resolution computed tomography (HRCT), pulmonary pressure (echo colour Doppler)), heart disease (standard and 24 ECG, echocardiography), cutaneous involvement (skin score), joint involvement (evidence of tender or swollen joints, or both), peripheral nervous system (PNS) involvement (electromyography), rheumatoid factor, angiotensin converting enzyme (fluorimetric method), von Willebrand factor (ELISA), and erythrocyte sedimentation rate (ESR) (Westergren). Results - Circulating NGF levels in SSc were significantly increased compared with controls (p
AB - Objective - To determine the circulating levels of nerve growth factor (NGF), neuropeptide Y (NPY), and vasoactive intestinal peptide (VIP) in systemic sclerosis (SSc), and to correlate these levels with clinical and laboratory features. Methods - Forty four patients with SSc were evaluated for circulating NGF (immunoenzymatic assay), NPY and VIP (radioimmunoassay), anticentromere and antitopoisomerase I autoantibodies, lung disease (pulmonary function tests with carbon monoxide transfer factor (TLCO), ventilation scintiscan with 99mTc DTPA radioaerosol, high resolution computed tomography (HRCT), pulmonary pressure (echo colour Doppler)), heart disease (standard and 24 ECG, echocardiography), cutaneous involvement (skin score), joint involvement (evidence of tender or swollen joints, or both), peripheral nervous system (PNS) involvement (electromyography), rheumatoid factor, angiotensin converting enzyme (fluorimetric method), von Willebrand factor (ELISA), and erythrocyte sedimentation rate (ESR) (Westergren). Results - Circulating NGF levels in SSc were significantly increased compared with controls (p
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U2 - 10.1136/ard.60.5.487
DO - 10.1136/ard.60.5.487
M3 - Article
C2 - 11302871
AN - SCOPUS:0035022631
VL - 60
SP - 487
EP - 494
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
SN - 0003-4967
IS - 5
ER -