Nerve growth factor and tissue repair remodeling: trkANGFR and p75NTR, two receptors one fate

Alessandra Micera, Alessandro Lambiase, Barbara Stampachiacchiere, Stefano Bonini, Sergio Bonini, Francesca Levi-Schaffer

Research output: Contribution to journalArticle

Abstract

This review deals with the role of nerve growth factor (NGF) in healing process as a result of injury. The role of both trkANGFR and p75NTR specific NGF receptors and their contribution in the complex network of tissue repair process, is discussed and highlighted in view of recent findings. In fact, NGF represents a significant advance in the treatment of etiologically different ulcers (corneal ulcers, pressure ulcers, post-viral infections, chemical burns) and might shorten the recovery process. For these diseases, no specific treatment is actually available. It is reasonable that apart from NGF and/or neurotrophins a different time-course of trkANGRF/p75NTR expression, might regulate the final process. In summary, these novel findings on the potential pro-healing capacity of NGF might open new possibilities for this growth factor in modulating the healing processes in several pathological conditions.

Original languageEnglish
Pages (from-to)245-256
Number of pages12
JournalCytokine and Growth Factor Reviews
Volume18
Issue number3-4
DOIs
Publication statusPublished - Jun 2007

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Keywords

  • Fibrosis
  • NGF
  • p75
  • trkA
  • Wound-healing

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)

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