Nerve growth factor and transforming growth factor-β serum levels in acute stroke patients: Possible involvement of neurotrophins in cerebrovascular disease

L. Stanzani, C. Zoia, G. Sala, I. Appollonio, L. Frattola, M. G. De Simoni, C. Ferrarese

Research output: Contribution to journalArticle

Abstract

Background and Purpose: Experimental evidence indicates cytokine and neurotrophin production in brain tissue after stroke. Since neurotrophins may also be released from blood cells, we measured nerve growth factor (NGF) and transforming growth factor (TGF)-β serum levels in 40 patients at various times after stroke and compared them to those in 20 healthy controls. Methods: Venous blood was obtained 1, 4, 10, 30 and 90 days after stroke and NGF and TGF-β serum levels were measured by commercial ELISA. Values at each time were correlated with stroke severity, assessed using the National Institute of Health Stroke Scale, and with lesion volume, calculated using Cavalieri's direct estimator on a computerized tomography scan performed 5 days after stroke. Results and Conclusions: Although no significant differences between the two groups were demonstrated, in stroke patients, serum neurotrophins were significantly associated with clinical and neuroradiological parameters of brain injury and positively correlated with each other in the acute phases of stroke, suggesting that stroke may modulate peripheral neurotrophin levels.

Original languageEnglish
Pages (from-to)240-244
Number of pages5
JournalCerebrovascular Diseases
Volume12
Issue number3
DOIs
Publication statusPublished - 2001

Keywords

  • Nerve growth factor
  • Neurotrophins
  • Serum
  • Stroke
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Clinical Neurology

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