Nerve growth factor as an angiogenic factor

Beatrice Nico, Domenica Mangieri, Vincenzo Benagiano, Enrico Crivellato, Domenico Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

Nerve growth factor (NGF), a neurotrophin that plays a crucial role in promoting neurotrophic and neurotropic effects in sympathetic neurons, has recently been identified as a novel angiogenic molecule, which exerts a variety of effects in the cardiovascular system and on endothelial cells. In fact, NGF may contribute to maintenance, survival, and function of endothelial cells by autocrine and/or paracrine mechanisms. This review summarizes the involvement of NGF in the regulation of angiogenesis in both normal and pathological conditions.

Original languageEnglish
Pages (from-to)135-141
Number of pages7
JournalMicrovascular Research
Volume75
Issue number2
DOIs
Publication statusPublished - Mar 2008

Keywords

  • Angiogenesis
  • Ischemia
  • Nerve growth factor
  • Tumor growth
  • Wound healing

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine

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