Nerve growth factor: Basic findings and clinical trials

Luigi Aloe, Alessandra Micera

Research output: Contribution to journalArticle

Abstract

The nerve growth factor is the first-discovered and best-characterized member of the family of neurotrophins. In the introduction of this article we present a briefbiographic view of past and present studies of Rita Levi-Montalcini on nerve growth factor. Further, the article focuses on pleiotropic activities of nerve growth factor, exerting on various cell types, including cells of nervous, immune and endocrine system. Implications of these actions of nerve growth factor in the pathogenesis of neurological diseases, autoimmune-inflammatory diseases, allergic diseases, lymphoproliferative diseases, atherosclerotic cardiovascular disease, and neurotrophic corneal ulcers are outlined.

Original languageEnglish
Pages (from-to)3-14
Number of pages12
JournalBiomedical Reviews
Volume10
Issue number1
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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