Nerve growth factor effects on the song control system of zebra finches

M. Fiore, S. N. Patel, E. Alleva, L. Aloe, N. S. Clayton

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The aim of this experiment was to test whether or not nerve growth factor (NGF) is involved in cholinergic processes in the avian brain, by injecting NGF into the higher vocal center (HVC) and examining its effects on adult male zebra finch song. Since NGF has been hypothesized to protect cells after injury, some birds received both NGF and ibotenic acid (IBO) lesions of HVC, while others received either NGF or IBO or neither (SHAM). Only the IBO-treated birds showed alterations in song. Although there was no evidence of cell preservation in the immunocytochemical and morphological analysis NGF appears to prevent the IBO induced impairment in song augmenting the activity of the remaining neurons and enhancing brain repair.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalNeuroscience Letters
Volume223
Issue number3
DOIs
Publication statusPublished - Feb 28 1997

Fingerprint

Finches
Equidae
Nerve Growth Factor
Music
Ibotenic Acid
High Vocal Center
Birds
Brain
Cholinergic Agents
Neurons
Wounds and Injuries

Keywords

  • ChAT
  • cholinergic system
  • higher vocal center
  • ibotenic acid
  • nerve growth factor
  • song
  • zebra finch

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fiore, M., Patel, S. N., Alleva, E., Aloe, L., & Clayton, N. S. (1997). Nerve growth factor effects on the song control system of zebra finches. Neuroscience Letters, 223(3), 161-164. https://doi.org/10.1016/S0304-3940(97)13425-5

Nerve growth factor effects on the song control system of zebra finches. / Fiore, M.; Patel, S. N.; Alleva, E.; Aloe, L.; Clayton, N. S.

In: Neuroscience Letters, Vol. 223, No. 3, 28.02.1997, p. 161-164.

Research output: Contribution to journalArticle

Fiore, M, Patel, SN, Alleva, E, Aloe, L & Clayton, NS 1997, 'Nerve growth factor effects on the song control system of zebra finches', Neuroscience Letters, vol. 223, no. 3, pp. 161-164. https://doi.org/10.1016/S0304-3940(97)13425-5
Fiore, M. ; Patel, S. N. ; Alleva, E. ; Aloe, L. ; Clayton, N. S. / Nerve growth factor effects on the song control system of zebra finches. In: Neuroscience Letters. 1997 ; Vol. 223, No. 3. pp. 161-164.
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