Recent studies suggest that nerve growth factor (NGF), a neurotrophic factor known to play a crucial role in neurite growth and differentiation, may also modulate vascular cell functions. In the present study, it was investigated whether NGF exhibits an angiogenic effect in a mouse model of hindlimb ischemia induced by femoral artery occlusion. Enzyme-linked immunosorbent assay determination revealed an enhanced endogenous NGF production (378±100 and 54±26 pg/g tissue in 7 day ischemic and normoperfused adductor muscles, respectively; P3; P3; P>0.05). In conclusion, the present study provides first evidence that NGF exerts angiogenic properties in vivo.
- Nerve growth factor
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