Nerve growth factor induces angiogenic activity in a mouse model of hindlimb ischemia

Paolo Turrini, Carlo Gaetano, Alessia Antonelli, Maurizio C. Capogrossi, Luigi Aloe

Research output: Contribution to journalArticlepeer-review

Abstract

Recent studies suggest that nerve growth factor (NGF), a neurotrophic factor known to play a crucial role in neurite growth and differentiation, may also modulate vascular cell functions. In the present study, it was investigated whether NGF exhibits an angiogenic effect in a mouse model of hindlimb ischemia induced by femoral artery occlusion. Enzyme-linked immunosorbent assay determination revealed an enhanced endogenous NGF production (378±100 and 54±26 pg/g tissue in 7 day ischemic and normoperfused adductor muscles, respectively; P3; P3; P>0.05). In conclusion, the present study provides first evidence that NGF exerts angiogenic properties in vivo.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalNeuroscience Letters
Volume323
Issue number2
DOIs
Publication statusPublished - Apr 26 2002

Keywords

  • Angiogenesis
  • Arteriogenesis
  • Arterioles
  • Capillaries
  • Hindlimb
  • Ischemia
  • Nerve growth factor

ASJC Scopus subject areas

  • Neuroscience(all)

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